Fol. Biol. 2013, 59, 1-14
https://doi.org/10.14712/fb2013059010001
Availability of Haematopoietic Niches for Transplanted Stem Cells
References
1. , G. B., Chabner, K. T., Alley, I. R., Olson, D. P., Szczepiorkowski, Z. M., Poznansky, M. C., Kos, C. H., Pollak, M. R., Brown, E. M., Scadden, D. T. (2006) Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 439, 599-603.
<https://doi.org/10.1038/nature04247>
2. , J., Borge, O. J., Bryder, D., Theilgaard-Monch, K., Astrand-Grunstrom, I,. Sitnicka, E., Sasaki, Y., Jacobsen, S. E. (2001) Upregulation of Flt-3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15, 659-669.
<https://doi.org/10.1016/S1074-7613(01)00220-5>
3. , F. R. (2007) Hematopoietic-cell transplantation at 50. N. Engl. J. Med. 357, 1472-1475.
<https://doi.org/10.1056/NEJMp078166>
4. , F., Suda, T. (2007) Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann. N.Y. Acad. Sci. 1106, 41-53.
<https://doi.org/10.1196/annals.1392.005>
5. , N., Zorina, T., Farkas, D. L., Shalit, I. (2002) Transplanted hematopoietic cells seed in clusters in recipient bone marrow in vivo. Stem Cells 20, 301-310.
<https://doi.org/10.1634/stemcells.20-4-301>
6. , N., Yolcu, E. S., Shirwan, H., Stein, J., Yaniv, I., Farkas, D. L. (2003) Characterization of adhesion and viability of early seeding hematopoietic cells in the host bone marrow in vivo and in situ. Exp. Hematol. 31, 1292-1300.
<https://doi.org/10.1016/j.exphem.2003.09.006>
7. , V., Nowlan, B., Lévesque, J. P., Winkler, I. G. (2012) Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells. Methods Mol. Biol. 844, 31-43.
<https://doi.org/10.1007/978-1-61779-527-5_3>
8. , J. E., Braun, J., McFarland-Starr, E. C. (1988) Erythrocyte replacement precedes leukocyte replacement during repopulation of W/Wv mice with limiting dilutions of +/+ donor marrow cells. Proc. Natl. Acad. Sci. USA 85, 7332-7335.
<https://doi.org/10.1073/pnas.85.19.7332>
9. , J. E., McFarland, E. C. (1988) Hematopoietic precursor cell defects in nonanemic but stem cell-deficient W44/W44 mice. J. Cell Physiol. 135, 533-538.
<https://doi.org/10.1002/jcp.1041350324>
10. , I., Bhattacharya, D., Zandi, S., Sigvardsson, M., Weissman I. L., Bryder, D., Rossi, D. J. (2010) Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc. Natl. Acad. Sci. USA 107, 5465-5470.
<https://doi.org/10.1073/pnas.1000834107>
11. , N. E., Kim, S., Lin, L., Walter, G. A., Scott, E. W. (2011) Ultra-high-field MRI real-time imaging of HSC engraftment of the bone marrow niche. Leukemia 25, 1223-1231.
<https://doi.org/10.1038/leu.2011.72>
12. , P., Cantin, C., Hyam, D., Iscove, N. N. (2003) Hematopoietic stem cells engraft in mice with absolute efficiency. Nat. Immunol. 4, 708-713.
<https://doi.org/10.1038/ni940>
13. , D. R., Boggs, S. S., Saxe D. F., Gress, L. A., Canfield, D. R. (1982) Hematopoietic stem cells with high proliferative potential. Assay of their concentration in marrow by the frequency and duration of cure of W/Wv mice. J. Clin. Invest. 70, 242-253.
<https://doi.org/10.1172/JCI110611>
14. , G., Cronkite, E. P. (1951) Post-radiation parabiosis and survival in rats. Proc. Soc. Exp. Biol. Med. 77, 292-294.
<https://doi.org/10.3181/00379727-77-18754>
15. , G., Ansell, J. D., Micklem, H. S., Tjio J. H., Cronkite, E. P. (1982) Special proliferative sites are not needed for seeding and proliferation of transfused bone marrow cells in normal syngeneic mice. Proc. Natl. Acad. Sci. USA 79, 5085-5087.
<https://doi.org/10.1073/pnas.79.16.5085>
16. , L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Divieti, P., Bringhurst, F. R., Milner,L. A., Kronenberg, H. M., Scadden, D. T. (2003) Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841-846.
<https://doi.org/10.1038/nature02040>
17. , A. (2008) Haematopoietic stem cell niches: interrelations between structure and function. Transfus. Apher. Sci. 38, 261-268.
<https://doi.org/10.1016/j.transci.2008.04.006>
18. , B., Hawley, R. G., Mintz, B. (1990) Longand shortlived murine hematopoietic stem cell clones individually identified with retroviral integration markers. Blood 75, 2267-2270.
<https://doi.org/10.1182/blood.V75.12.2267.2267>
19. , B., Stephenson, D. A., Chapman, V. M., Besmer, P., Bernstein, A. (1988) The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335, 88-89.
<https://doi.org/10.1038/335088a0>
20. , G. A., Boles, N., Lin, K. K. Y., Goodell, M. A. (2009) Mouse hematopoietic stem cell identification and analysis. Cytometry A 75, 14-24.
<https://doi.org/10.1002/cyto.a.20674>
21. , G. A., Boles, N., Chambers, S. M., Goodell, M. A. (2010) Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-β1. Cell Stem Cell 6, 265-276.
<https://doi.org/10.1016/j.stem.2010.02.002>
22. , J. L., Gurevitch, O. A., Udalov G. A. (1980) Role of bone marrow stroma in hematopoietic stem cell regulation. Exp. Hematol. 8, 770-778.
23. , S. H., Morrison, S. J., Liao X., Weissman, I. L. (1999) In vivo proliferation and cell cycle kinetics of longterm self-renewing hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 96, 3120-3125.
<https://doi.org/10.1073/pnas.96.6.3120>
24. , R. H., Sieburg, H. B., Muller-Sieburg, C. E. (2008) A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 111, 5553-5561.
<https://doi.org/10.1182/blood-2007-11-123547>
25. , M. A., Martin-Zanca, D., Soucek, L., Lawlor, E. R., Brown-Swigart, L., Verschuren, E. W., Evan, G. I. (2005) Temporal dissection of p53 function in vitro and in vivo. Nat. Genet. 37, 718-726.
<https://doi.org/10.1038/ng1572>
26. , G. A., Lambert, J. F., Abedi, M., Hsieh, C. C., Carlson, J. E., Stewart, F. M., Quesenberry, P. J. (2004) Murine marrow cellularity and the concept of stem cell competition: geographic and quantitative determinants in stem cell biology. Leukemia 18, 575-583.
<https://doi.org/10.1038/sj.leu.2403268>
27. , A., Kraft, D., Weissman, I. L., Bhattacharya, D. (2007) Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science 318, 1296-1299.
<https://doi.org/10.1126/science.1149726>
28. , M., Rasini, V., Bussolari, R., Chen, X., Hofmann, T. J., Spano, C., Bernabei, D., Veronesi, E., Bertoni, F., Paolucci, P., Conte, P., Horwitz, E. M. (2009) Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation. Blood 114, 2333-2343.
<https://doi.org/10.1182/blood-2008-10-183459>
29. , J. D., Tarbell, N. J., Thames, H. D., Mauch, P. M. (1991) Syngeneic and allogeneic bone marrow engraftment after total body irradiation: dependence on dose, dose rate, and fractionation. Blood 77, 661-669.
<https://doi.org/10.1182/blood.V77.3.661.661>
30. , J. D., Ploemacher, R. E. (1993) Transient and permanent engraftment potential of murine hematopoietic stem cell subsets: differential effects of host conditioning with γ radiation and cytotoxic drugs. Exp. Hematol. 21, 913-921.
31. , N. J., Keller, J. R., Chertkov, J. L. (1996) Local clonal analysis of the hematopoietic system shows that multiple small short-living clones maintain life-long hematopoiesis in reconstituted mice. Blood 88, 2927-2938.
<https://doi.org/10.1182/blood.V88.8.2927.bloodjournal8882927>
32. , B., Kent, D., Bowie, M., McCaffrey, L., Hamilton, M., Lyons, K., Lee, S. J., Brinkman, R., Eaves, C. (2007) Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 1, 218-229.
<https://doi.org/10.1016/j.stem.2007.05.015>
33. , A., Trumpp, A. (2011) The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. J. Exp. Med. 208, 421-428.
<https://doi.org/10.1084/jem.20110132>
34. , H., Sudo, K., Seita, J., Matsubara, A., Morita, Y., Osawa, M., Takatsu, K., Takaki, S., Nakauchi, H. (2005) Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. Dev. Cell 8, 907-914.
<https://doi.org/10.1016/j.devcel.2005.03.019>
35. , N. M., Krauss, A. C., Guimond, M., Meadors, J. L., Dobre, S., Mackall, C. L. (2010) Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation. Blood 115, 4120-4129.
<https://doi.org/10.1182/blood-2009-10-248898>
36. , C. E., Hamerton, J. L., Barnes, D. W., Loutit, J. F. (1956) Cytological identification of radiation chimaeras. Nature 177, 452-454.
<https://doi.org/10.1038/177452a0>
37. , E. C., Prohaska, S. S., Katzman, S., Heffner, G. C., Stuart, J. M., Weissman, I. L. (2005) Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet. 1, e28.
<https://doi.org/10.1371/journal.pgen.0010028>
38. , E. N., Russel, E. S. (1983) Analysis of the hematopoietic effects of new dominant spotting (W) mutations of the mouse. I. Influence upon hematopoietic stem cells. Exp. Hematol. 11, 452-460.
39. , E. N., Ryan, M. A., Housman, D. E. (1988) The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55, 185-192.
<https://doi.org/10.1016/0092-8674(88)90020-7>
40. , W. S., Pech, N. K., Meyers, J. L., Srour, E. F., Yoder, M. C., Dinauer, M. C. (2004) A murine model of antimetabolite-based, submyeloablative conditioning for bone marrow transplantation: biologic insights and potential applications. Exp. Hematol. 32, 1255-1264.
<https://doi.org/10.1016/j.exphem.2004.08.007>
41. , M. A., Brose, K., Paradis, G., Conner, A. S., Mulligan, R. C. (1996) Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 183, 1797-1806.
<https://doi.org/10.1084/jem.183.4.1797>
42. , D. E., Adler, B. J., Chan, M. E., Rubin, C. T. (2012) Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity. J. Bone Miner. Res. 27, 749-759.
<https://doi.org/10.1002/jbmr.1505>
43. , D. E. (1972) Life sparing ability (in lethally irradiated mice) of W/Wv mouse marrow with no macroscopic colonies. Radiat. Res. 52, 553-563.
<https://doi.org/10.2307/3573514>
44. , D. E., Stone, M., Astle, C. M. (1990) Effects of transplantation on the primitive immunohematopoietic stem cell. J. Exp. Med. 172, 431-437.
<https://doi.org/10.1084/jem.172.2.431>
45. , T., Šefc, L., Chang, K. T., Savvulidi, F., Michalová, J., Nečas, E. (2012) B-lymphopoiesis gains sensitivity to subsequent inhibition by estrogens during final phase of fetal development. Dev. Comp. Immunol. 36, 385-389.
<https://doi.org/10.1016/j.dci.2011.07.009>
46. , X., Cho, S., Spangrude, G. J. (2007) Hematopoietic stem cells: generation and self-renewal. Cell Death Differ. 14, 1851-1859.
<https://doi.org/10.1038/sj.cdd.4402225>
47. , Y., Chen, B. J., Deoliveira, D., Mito, J., Chao, N. J. (2010) Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model. PLoS One 5, e11316.
<https://doi.org/10.1371/journal.pone.0011316>
48. , M. J., Yilmaz, O. H., Iwashita, T., Terhorst, C., Morrison, S. J. (2005) SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109-1121.
<https://doi.org/10.1016/j.cell.2005.05.026>
49. , M. J., Morrison, S. J. (2008) Uncertainty in the niches that maintain hematopoietic stem cells. Nat. Rev. Immunol. 8, 290-301.
<https://doi.org/10.1038/nri2279>
50. , S. M., Collector, M. I., Sharkis, S. J. (1999) Hematopoietic stem cell tracking in vivo: a comparison of shortterm and long-term repopulating cells. Blood 93, 1916-1921.
<https://doi.org/10.1182/blood.V93.6.1916.406k15_1916_1921>
51. , T., Dar, A., Kollet, O. (2005) How do stem cells find their way home? Blood 106, 1901-1910.
<https://doi.org/10.1182/blood-2005-04-1417>
52. , X. M., Hu, Z., Jorgenson, M. L., Wingard, J. R., Slayton, W. B. (2008) Bone marrow sinusoidal endothelial cells undergo nonapoptotic cell death and are replaced by proliferating sinusoidal cells in situ to maintain the vascular niche following lethal irradiation. Exp. Hematol. 36, 1143-1156.
<https://doi.org/10.1016/j.exphem.2008.06.009>
53. Celso, C., Wu, J. W., Lin, C. P. (2009) In vivo imaging of hematopoietic stem cells and their microenvironment. J. Biophotonics 2, 619-631.
54. , R., Neff, N. F., Quake, S. R., Weissman, I. L. (2011) Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding. Nat. Biotechnol. 29, 928-933.
<https://doi.org/10.1038/nbt.1977>
55. , M. A., Dorie, M. J., Lamela, R. A., Rogers, Z. R., Patt, H. M. (1978) Hematopoietic stem cell regulatory volumes as revealed in studies of the bgj/bgj:W/Wv chimera. J. Exp. Med. 147, 1189-1197.
<https://doi.org/10.1084/jem.147.4.1189>
56. , M. A., Lamela, R. A., Banda, M. J., Patt, H. M. (1982) Partitioning of bone marrow into stem cell regulatory domains. Proc. Natl. Acad. Sci. USA 79, 840-844.
<https://doi.org/10.1073/pnas.79.3.840>
57. , A., Porter, C. C., Zaberezhnyy, V., DeGregori, J. (2010) Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol. 8, e1000324.
<https://doi.org/10.1371/journal.pbio.1000324>
58. , Y., Kinjo, K., Mulligan, R. C., Okano, H. (2004) Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. Immunity 20, 87-93.
<https://doi.org/10.1016/S1074-7613(03)00354-6>
59. , P., Down, J. D., Warhol, M., Hellman, S. (1988) Recipient preparation for bone marrow transplantation. I. Efficacy of total-body irradiation and busulfan. Transplantation 46, 205-210.
<https://doi.org/10.1097/00007890-198808000-00004>
60. , A. A. (1909) Der Lymphocyt als gemeinsame Stammzelle der verschiedenen Blutelemente in der embryonalen Entwicklung und im postfetalen Leben der Säugetiere. Folia Haematol. 8, 125-134. (In German).
61. , K. F. (1997) Population size and radiosensitivity of murine hematopoietic endogenous long-term repopulating cells. Blood 89, 834-841.
<https://doi.org/10.1182/blood.V89.3.834>
62. , J., Savvulidi, F., Sefc, L., Faltusova, K., Forgacova, K., Necas, E. (2011) Hematopoietic stem cells survive circulation arrest and reconstitute hematopoiesis in myeloablated mice. Biol. Blood Marrow Transplant. 17, 1273-1281.
<https://doi.org/10.1016/j.bbmt.2011.07.007>
63. , H. S., Clarke, C. M., Evans, E. P., Ford, C. E. (1968) Fate of chromosome-marked mouse bone marrow cells transfused into normal syngeneic recipients. Transplantation 6, 299-302.
64. , H. S., Lennon, J. E., Ansell, J. D., Gray, R. A. (1987) Numbers and dispersion of repopulating hematopoietic cell clones in radiation chimeras as functions of injected cell dose. Exp. Hematol. 15, 251-257.
65. , Y., Ema, H., Nakauchi, H. (2010) Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J. Exp. Med. 207, 1173-1182.
<https://doi.org/10.1084/jem.20091318>
66. , H. (2011) Role of transcription factors in differentiation and reprogramming of hematopoietic cells. Keio J. Med. 60, 47-55.
<https://doi.org/10.2302/kjm.60.47>
67. , E., Znojil, V. (1987) CFU-S content and cycling rate in several strains of mice. Exp. Hematol. 15, 759-764.
68. , E., Znojil, V. (1988) Bone marrow response to small doses of irradiation: implications for stem cell functional organization. Exp. Hematol. 16, 871-875.
69. , E., Znojil, V., Šefc, L. (1990) Hematopoietic stem cells: spleen colony-forming cells are normally actively proliferating. Cell Tissue Kinet. 23, 637-649.
70. , E., Šefc, L., Brecher, G., Bookstein N. (1995) Hematopoietic reserve provided by spleen colony-forming units (CFU-S). Exp. Hematol. 23, 1242-1246.
71. , E., Šefc, L., Šulc, K., Barthel, E., Seidel, H. J. (1998) Estimation of extent of cell death in different stages of normal murine hematopoiesis. Stem Cells 16, 107-111.
<https://doi.org/10.1002/stem.160107>
72. , A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N. P., Crockford, T. L., Cabuy, E., Vindigni, A., Enver, T., Bell, J. I., Slijecevic, P., Goodnow, C. C., Jeggo, P. A., Cornall R. J. (2007) DNA repair is limiting for hematopoietic stem cell during ageing. Nature 447, 686-690.
<https://doi.org/10.1038/nature05875>
73. , S. K., Dooner, M. S., Quesenberry, P. J. (1997) Synchronized cell-cycle induction of engrafting long-term repopulating stem cells. Blood 90, 4646-4650.
<https://doi.org/10.1182/blood.V90.11.4646>
74. , S. K., Haylock, D. N., Johnston, H. M., Occhiodoro, T., Brown, T. J., Simmons, P. J. (2003) Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro. Blood 101, 856-862.
<https://doi.org/10.1182/blood-2002-05-1344>
75. , J., Necas, E. (1994) Proliferation-differentiation pathways of murine hematopoiesis: correlation of lineage fluxes. Cell Prolif. 27, 597-633.
<https://doi.org/10.1111/j.1365-2184.1994.tb01377.x>
76. , M., Hanada, K., Hamada, H., Nakauchi, H. (1996) Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273, 242-245.
<https://doi.org/10.1126/science.273.5272.242>
77. , T., Chang, K. T., Šefc, L., Savvulidi, F., Broulík, P., Nečas, E. (2008) The late-stage foetal liver microenvironment is essential for later sensitivity of B-lymphocytes to suppression by oestrogens. Folia Biol. (Praha) 54, 125-129.
78. , O. I., Kuchenbauer, F., Delaney, A. D., Lecault, V., White, A., Kent, D., Marmolejo, L., Heuser, M., Berg, T., Copley, M., Ruschmann, J., Sekulovic, S., Benz, C., Kuroda, E., Ho, V., Antignano ,F., Halim, T., Giambra ,V., Krystal, G., Takei, C. J., Weng, A. P., Piret, H., Eaves, C., Marra, M. A., Humphries, R. K., Hansen C. L. (2010) Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc. Natl. Acad. Sci. USA 107, 15443-15448.
<https://doi.org/10.1073/pnas.1009320107>
79. , P. J., Colvin, G. A., Lambert, J. F. (2002) The chiaroscuro stem cell: a unified stem cell theory. Blood 100, 4266-4271.
<https://doi.org/10.1182/blood-2002-04-1246>
80. , P. J., Aliotta, J. M. (2008) The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles. Stem Cell Rev. 4, 137-147.
<https://doi.org/10.1007/s12015-008-9036-y>
81. , S. S., Peters, S. O., Crittenden, R. B., Stewart F. M., Ramshaw, H. S., Quesenberry, P. J. (1997) Stem cell transplantation in the normal nonmyeloablated host: relationship between cell dose, schedule, and engraftment. Exp. Hematol. 25, 114-121.
82. , S., van Os, R., Sheridan, T., Mauch, P. (2000) Reduction of marrow hematopoietic progenitor and stem cell content is not sufficient for enhanced syngeneic engraftment. Stem Cells 18, 93-101.
<https://doi.org/10.1634/stemcells.18-2-93>
83. , R. J., Anderson, R. M. (2011) Cellular senescence – its role in cancer and the response to ionizing radiation. Genome Integr. 2, 7.
<https://doi.org/10.1186/2041-9414-2-7>
84. , D. F., Boggs, S. S., Boggs, D. R. (1984) Transplantation of chromosomally marked syngeneic marrow cells into mice not subjected to hematopoietic stem cell depletion. Exp. Hematol. 12, 277-283.
85. , R. (1978) The relationship between the spleen colony-forming cell and the hematopoietic stem cell. Blood Cells 4, 7-25.
86. , L., Pšenák, O., Sýkora, V., Šulc, K., Nečas, E. (2003) Response of hematopoiesis to cyclophosphamide follows highly specific patterns in bone marrow and spleen. J. Hematother. Stem Cell Res. 12, 47-61.
<https://doi.org/10.1089/152581603321210136>
87. , L., Sun, Y., Zhang, Z., Feng, W., Gao, Y., Cai, Z., Wang, Z. Z., Look, A. T., Wu, W. S. (2010) Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood 115, 4707-4714.
<https://doi.org/10.1182/blood-2009-10-248872>
88. , Y., Astle, C. M., Harrison, D. E.(2007) Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function. Exp. Hematol. 35, 214-220.
<https://doi.org/10.1016/j.exphem.2006.10.001>
89. , H. B., Cho, R. H., Dykstra, B., Uchida, N., Eaves, C. J., Muller-Sienburg, C. E. (2006) The hematopoietic stem cell compartment consists of a limited number of discrete stem cell subsets. Blood 107, 2311-2316.
<https://doi.org/10.1182/blood-2005-07-2970>
90. , G. J., Johnson, G. R. (1990) Resting and activated subsets of mouse multipotent hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 97, 7433-7437.
<https://doi.org/10.1073/pnas.87.19.7433>
91. , F. M., Crittenden, R. B., Lowry P. A., Pearson-White, S., Quesenberry, P. J. (1993) Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice. Blood 81, 2566-2571.
<https://doi.org/10.1182/blood.V81.10.2566.2566>
92. , N., Yamazaki, S., Ema, H., Yamaguchi, T., Nakauchi, H., Takaki, S. (2012) Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xL. Exp. Hematol. 40, 166-174.
<https://doi.org/10.1016/j.exphem.2011.11.003>
93. , S., Morita, H., Tezuka, Y., Takatsu, K. (2002) Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk. J. Exp. Med. 195, 151-160.
<https://doi.org/10.1084/jem.20011170>
94. , J. E., McCulloch, E. A. (1961) A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14, 213-222.
<https://doi.org/10.2307/3570892>
95. , D., Šinkora, J., Vávrová, J., Řezáčová, M., Knížek, J., Östereicher, J. (2006) CD8+ natural killer cells have a potential of a sensitive and reliable biodosimetric marker in vitro. Physiol. Res. 55, 689-698.
<https://doi.org/10.33549/physiolres.930991>
96. , M., Semeluk, A., Wegmann, T. G. (1987) Facilitation of syngeneic stem cell engraftment by anti-class I monoclonal antibody pretreatment of unirradiated recipients. Transplantation 44, 487-494.
<https://doi.org/10.1097/00007890-198710000-00006>
97. , S. M., Zhang, M. Q. (2010) Transcriptome study for early hematopoiesis – achievement, challenge and new opportunity. J. Cell Physiol. 223, 549-552.
<https://doi.org/10.1002/jcp.22065>
98. , Z., Li, G., Tse, W., Bunting, K. D. (2009) Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood 113, 4856-4865.
<https://doi.org/10.1182/blood-2008-09-181107>
99. , C., Madan, V., Bartels, S., Costa, C., Blasig, R., Rodewald, H. R. (2009) Hematopoietic stem cell transplantation without irradiation. Nat. Methods 6, 267-269.
<https://doi.org/10.1038/nmeth.1309>
100. , A., Oser, G.,M., Jaworski, M., Blanco-Bose, W. E., Laurenti, E., Adolphe, C., Essers, M. A., MacDonald, H. R., Trumpp A. (2007) Dormant and self-renewing hematopoietic stem cells and their niches. Ann. N.Y. Acad. Sci. 1106, 64-75.
<https://doi.org/10.1196/annals.1392.021>
101. , A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., Lió, P., MacDonald, H. R., Trumpp, A. (2008) Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135, 1118-1129.
<https://doi.org/10.1016/j.cell.2008.10.048>
102. , D. D., Keating, A. (1993) Hematopoietic stem cells engraft in untreated transplant recipients. Exp. Hematol. 21, 251-256.
103. , Y., Yin, T., Wiegraebe, W., He, X. C., Miller, D., Stark, D., Perko, K., Alexander, R., Schwartz, J., Grindley, J. C., Park, J., Haug, J. S., Wunderlich, J. P., Li, H., Zhang, S., Johnson, T., Feldman, R. A., Li, L. (2009) Detection of functional haematopoietic stem cell niche using real-time imaging. Nature 457, 97-101.
<https://doi.org/10.1038/nature07639>
104. , X., Pech, N. K., Shelley, W. C., Srour, E. F., Yoder, M. C., Dinauer, M. C. (2010) Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice. Blood 116, 5419-5422.
<https://doi.org/10.1182/blood-2010-07-295949>
105. , T., Li, L. (2006) The stem cell niches in the bone. J. Clin. Invest. 116, 1195-1201.
<https://doi.org/10.1172/JCI28568>
106. , M., Tomita, Y., Uchida, T., Zhang, Q. W., Nomoto, K. (2000) Inability of cyclophosphamide-induced tolerance to permit engraftment of pluripotent stem cells contained in a moderate number of syngeneic bone marrow cells. Immunobiology 201, 552-567.
<https://doi.org/10.1016/S0171-2985(00)80074-1>
107. , M., Shinohara, T., Heike, T., Shiota, M., Kanatsu-Shinohara, M., Nakahata, T. (2003) Direct visualization of transplanted hematopoietic cell reconstitution in intact mouse organs indicates the presence of a niche. Exp. Hematol. 31, 733-740.
<https://doi.org/10.1016/S0301-472X(03)00108-5>
108. , H., Shen, H., Yuan, Y., XuFeng, R., Hu, X., Garrison, S. P., Zhang, L., Yu, J., Zambetti, G. P., Cheng T. (2010) Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation. Blood 115, 3472-3480.
<https://doi.org/10.1182/blood-2009-10-248278>
