Fol. Biol. 2013, 59, 168-171
Tagging rs10811661 Variant at CDKN2A/2B Locus Is Not Associated with Type 2 Diabetes Mellitus in Czech Population
Genome-wide association studies have resulted in the identification of the CDKN2A/2B locus as an important genetic determinant of type 2 diabetes mellitus development. The aim of this study was to investigate the role of this locus in the development of type 2 diabetes mellitus in Czech Slavonic population. Groups of 1,149 type 2 diabetic patients and a group of 2,312 healthy controls, both of Czech origin, were successfully genotyped for the rs10811661 CDKN2A/2B tagging polymorphism. The “risky” TT genotype frequencies were almost identical in both examined groups (69.3 % in patients and 68.9 % in controls, P = 0.52; OR [95% CI] = 1.02 [0.87 – 1.19] for TT versus C allele carriers). Similar negative results were obtained when males (P = 0.93) and females (P = 0.23) were analysed separately. We have not confirmed the association between rs10811661 SNP and susceptibility to the type 2 diabetes mellitus in Czech Slavonic population.
Keywords
Funding
This work was supported by the project of the Ministry of Health of the Czech Republic – Development of Research Organization (Institute for Clinical and Experimental Medicine – IKEM, IN 00023001).
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.
