Correlated Increase of Omentin-1 and Adiponectin by Exenatide, Avandamet and Dietary Change in Diet-Induced Obese Rats

Feng, W.-H.; Yuan, X.-W.; Tong, G.-Y.; Wang, W.-M.; Hu, Y.; Shen, S.-M.; Li, P.; Bi, Y.; Hu, J.; Shao, L.-L.; Dai, Y.-Y.; Liu, Y.-Q.; Xiang, S.-K.; Yang, D.-H.; Zhu, Da-Long

doi:10.14712/fb2013059060217

Folia Biologica > Archive > 2013, Vol. 59 > Issue 6 > Correlated Increase of Omentin-1 and…

Fol. Biol. 2013, 59, 217-224

https://doi.org/10.14712/fb2013059060217

Correlated Increase of Omentin-1 and Adiponectin by Exenatide, Avandamet and Dietary Change in Diet-Induced Obese Rats

W.-H. Feng¹, X.-W. Yuan², G.-Y. Tong¹, W.-M. Wang¹, Y. Hu¹, S.-M. Shen¹, P. Li¹, Y. Bi¹, J. Hu¹, L.-L. Shao³, Y.-Y. Dai⁴, Y.-Q. Liu⁴, S.-K. Xiang⁵, D.-H. Yang¹, Da-Long Zhu¹

¹Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing Medical University, Nanjing, China
²Department of Endocrinology, Nanjing Children’s Hospital Affiliated to Nanjing Medical University, Nanjing, China
³Nanjing University of Chinese Medicine, Nanjing, China
⁴Medical School of Southeast University, Nanjing, China
⁵Department of Endocrinology, Changzhou First People’s Hospital, Nanjing, China

Received September 2013
Accepted October 2013

Adipokines omentin-1 and adiponectin have been reported to improve insulin resistance. It is known that insulin sensitizers exenatide, avandamet, or diet change from high-fat to normal chow ameliorate metabolic disorders. However, whether these treatments increase omentin-1 levels in high fat-diet animals and the relationship between omentin-1 and adiponectin remain largely unknown. We investigated the effect of insulin sensitizers exenatide and avandamet, and of dietary change on these adipokine levels, body weight, and insulin sensitivity in diet-induced obese rats. Obesity was induced in rats by high-fat diet feeding for 8 weeks, and then the rats were given exenatide, avandamet and diet change to normal chow, respectively, for additional 8 weeks. Compared to the high-fat control group, exenatide and avandamet treatment significantly induced adipose gene expression and elevated the circulation levels of omentin-1 and adiponectin, whereas they decreased the leptin gene expression and circulation level, which is associated with improvement of systemic insulin sensitivity and the glucose and lipid profile. Notably, there was a significant positive correlation between omentin-1 and adiponectin in the above regimens, suggesting that omentin-1 and adiponectin may contribute to the insulin-sensitizing effect of exenatide and avandamet.

Keywords

exenatide, avandamet, dietary change, obesity, adipokines.

Funding

This work was supported by grants from the National Natural Science Foundation of China (81000350), Natural Science Foundation of Jiangsu province of China (grant number BK2008061) and medical and health research projects of Nanjing Health Bureau in Jiangsu province of China (grant number 201108017, YKK11092).