Fol. Biol. 2013, 59, 246-252

https://doi.org/10.14712/fb2013059060246

Association of Gln223Arg Polymorphism of the Leptin Receptor with Hypertensive Left Ventricular Hypertrophy

H. Zheng1, N. Xie1, H. Xu2, J. Huang1, X. Xie1, Ming Luo1

1Geriatrics Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China
2Cardiology Department, Tongji Hospital Affiliated to Tongji University, Shanghai, China

Received June 2013
Accepted October 2013

References

1. Gradman A., H., Altayoumi, F. (2006) From left ventricular hypertrophy to congestive heart failure: management of hypertensive heart disease. Prog. Cardiovasc. Dis. 48, 326-341. <https://doi.org/10.1016/j.pcad.2006.02.001>
2. Barouch, L. A., Berkowitz, D. E., Harrison, R. W., O’Donnell, C. P., Hare, J. M. (2003) Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 108, 754-759. <https://doi.org/10.1161/01.CIR.0000083716.82622.FD>
3. Bella, J. N., MacCluer, J. W., Roman, M. J., Almasy, L., North, K. E., Best, L. G., Lee, E. T., Fabsitz, R. R., Howard, B. V. (2004) Heritability of left ventricular dimensions and mass in American Indians: The Strong Heart Study. J. Hypertens. 22, 281-286. <https://doi.org/10.1097/00004872-200402000-00011>
4. Bjorbaek, C., Kahn, B. B. (2004) Leptin signaling in the central nervous system and the periphery. Recent Prog. Horm. Res. 59, 305-331. <https://doi.org/10.1210/rp.59.1.305>
5. Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., Caro, J. F. (1996) Serum immunoreactive­leptin concentrations in normal­weight and obese humans. N. Engl. J. Med. 334, 292-295. <https://doi.org/10.1056/NEJM199602013340503>
6. Endo, K., Yanagi, H., Hirano, C., Hamaguchi, H., Tsuchiya, S., Tomura, S. (2000) Association of Trp64Arg polymorphism of the β3-adrenergic receptor gene and no association of Gln223Arg polymorphism of the leptin receptor gene in Japanese school children with obesity. Int. J. Obes. Relat. Metab. Disord. 24, 443-439. <https://doi.org/10.1038/sj.ijo.0801177>
7. Enns, J. E., Taylor, C. G., Zahradka, P. (2011) Variations in adipokine genes Adipo Q, Lep and LepR are associated with risk for obesity-related metabolic disease: the modulatory role of gene­nutrient interactions. J. Obes. 2011, ID 168659.
8. Fabre, A., Sheppard, M. N. (2006) Sudden adult death syndrome and other non­ischaemic causes of sudden cardiac death. Heart 92, 316-320. <https://doi.org/10.1136/hrt.2004.045518>
9. Friedman, J. M., Halaas, J. L. (1998) Leptin and the regulation of body weight in mammals. Nature 395, 763-770. <https://doi.org/10.1038/27376>
10. Gan, R. T., Yang, S. S. (2012) The 223A>G polymorphism of the leptin receptor gene is associated with macroangiopathy in type 2 diabetes mellitus. Mol. Biol. Rep. 39, 4759-4764. <https://doi.org/10.1007/s11033-011-1268-2>
11. Gottlieb, M. G., Bodanese, L. C., Leite, L. E., Schwanke, C. H., Piccoli, J. C., da Rocha, M. I., da Cruz, I. B. (2009) Association between the Gln223Arg polymorphism of the leptin receptor and metabolic syndrome in free­living community elderly. Metab. Syndr. Relat. Disord. 7, 341-348. <https://doi.org/10.1089/met.2008.0029>
12. Gu, P., Jiang, W., Chen, M., Lu, B., Shao, J., Du, H., Jiang, S. (2012) Association of leptin receptor gene polymorphisms and essential hypertension in a Chinese population. J. Endocrinol. Invest. 35, 859-865.
13. Jin, Y., Kuznetsova, T., Bochud, M., Richart, T., Thijs, L., Cusi, D., Fagard, R., Staessen, J. A. (2011) Heritability of left ventricular structure and function in Caucasian families. Eur. J. Echocardiogr. 12, 326-332.
14. Komşu-Ornek, Z., Demirel, F., Dursun, A., Ermiş, B., Pişkin, E., Bideci, A. (2012) Leptin receptor gene Gln223Arg polymorphism is not associated with obesity and metabolic syndrome in Turkish children. Turk. J. Pediatr. 54, 20-24.
15. Konstantinides, S., Schäfer, K., Koschnick, S., Loskutoff, D. J. (2001) Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J. Clin. Invest. 108, 1533-1540. <https://doi.org/10.1172/JCI13143>
16. Kshatriya, S., Liu, K., Salah, A., Szombathy, T., Freeman, R. H., Reams, G. P., Spear, R. M., Villarreal, D. (2011) Obesity hypertension: the regulatory role of leptin. Int. J. Hypertens. 270624. <https://doi.org/10.4061/2011/270624>
17. Kullo, I. J., Turner, S. T., Boerwinkle, E., Kardia, S. L., de Andrade, M. (2005) A novel quantitative trait locus on chromosome 1 with pleiotropic effects on HDL­cholesterol and LDL particle size in hypertensive sibships. Am. J. Hypertens. 18, 1084-1890. <https://doi.org/10.1016/j.amjhyper.2005.02.010>
18. Mark, A. L., Agassandian, K., Morgan, D. A., Liu, X., Cassell, M. D., Rahmouni, K. (2009) Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney. Hypertension 53, 375-380. <https://doi.org/10.1161/HYPERTENSIONAHA.108.124255>
19. Morton, N. M., Emilsson, V., de Groot, P., Pallett, A. L., Cawthorne, M. A. (1999) Leptin signalling in pancreatic islets and clonal insulin secreting cells. J. Mol. Endocrinol. 22, 173-184. <https://doi.org/10.1677/jme.0.0220173>
20. Muoio, D. M., Dohm, G. L., Fiedorek Jr. F. T., Tapscott, E. B., Coleman, R. A., Dohn, G. L. (1997) Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46, 1360-1363. <https://doi.org/10.2337/diab.46.8.1360>
21. Nagae, A., Fujita, M., Kawarazaki, H., Matsui, H., Ando, K., Fujita, T. (2009) Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension. Circulation 119, 978-986. <https://doi.org/10.1161/CIRCULATIONAHA.108.824730>
22. Perego, L., Pizzocri, P., Corradi, D., Maisano, F., Paganelli, M., Fiorina, P., Barbieri, M., Morabito, A., Paolisso, G., Folli, F., Pontiroli, A. E. (2005) Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy. J. Clin. Endocrinol. Metab. 90, 4087-4093. <https://doi.org/10.1210/jc.2004-1963>
23. Post, W. S., Larson, M. G., Myers, R. H., Galderisi, M., Levy, D. (1997) Heritability of left ventricular mass: the Framingham Heart Study. Hypertension 30, 1025-1028. <https://doi.org/10.1161/01.HYP.30.5.1025>
24. Pyrzak, B., Wisniewska, A., Kucharska, A., Wasik, M., Demkow, U. (2009) No association of LEPR Gln223Arg polymorphism with leptin, obesity or metabolic disturbances in children. Eur. J. Med. Res. 14, 201-204. <https://doi.org/10.1186/2047-783X-14-S4-201>
25. Purdham, D. M., Rajapurohitam, V., Zeidan, A., Huang, C., Gross, G. J., Karmazyn, M. (2008) A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart. Am. J. Physiol. Heart Circ. Physiol. 295, H441-446. <https://doi.org/10.1152/ajpheart.91537.2007>
26. Rajapurohitam, V., Gan, X. T., Kirshenbaum, L. A., Karmazyn, M. (2003) The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ. Res. 93, 277-279. <https://doi.org/10.1161/01.RES.0000089255.37804.72>
27. Rajapurohitam, V., Javadov, S., Purdham, D. M., Kirshenbaum, L. A., Karmazyn, M. (2006) An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin­1. J. Moll. Cell. Cardiol. 4, 265-274. <https://doi.org/10.1016/j.yjmcc.2006.05.001>
28. Romero­Corral, A., Sierra­Johnson, J., Lopez­Jimenez, F., Thomas, R. J., Singh, P., Hoffmann, M., Okcay, A., Korinek, J., Wolk, R., Somers, V. K. (2008) Relationships between leptin and C­reactive protein with cardiovascular disease in the adult general population. Nat. Clin. Pract. Cardiovasc. Med. 5, 418-425. <https://doi.org/10.1038/ncpcardio1218>
29. Saukko, M., Kesäniemi, Y. A., Ukkola, O. (2010) Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis. Metab. Syndr. Relat. Disord. 8, 425-430. <https://doi.org/10.1089/met.2010.0004>
30. Shimabukuro, M., Koyama, K., Chen, G., Wang, M. Y., Trieu, F., Lee, Y., Newgard, C. B., Unger, R. H. (1997) Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc. Natl. Acad. Sci. USA 94, 4637-4641. <https://doi.org/10.1073/pnas.94.9.4637>
31. Sierra-Honigmann, M. R., Nath, A. K., Murakami, C., García-Cardeña, G., Papapetropoulos, A., Sessa, W. C., Madge, L. A., Schechner, J. S., Schwabb, M. B., Polverini, P. J., Flores-Riveros, J. R. (1998) Biological action of leptin as an angiogenic factor. Science 281, 1683-1686. <https://doi.org/10.1126/science.281.5383.1683>
32. Sinha, M. K., Opentanova, I., Ohannesian, J. P., Kolaczynski, J. W., Heiman, M. L., Hale, J., Becker, G. W., Bowsher, R. R., Stephens, T. W., Caro, J. F. (1996) Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short­term fasting. J. Clin. Invest. 98, 1277-1282. <https://doi.org/10.1172/JCI118913>
33. Soro, A., Jauhiainen, M., Ehnholm, C., Taskinen, M. R. (2003) Determinants of low HDL levels in familial combined hyperlipidemia. J. Lipid Res. 44, 1536-1544. <https://doi.org/10.1194/jlr.M300069-JLR200>
34. Stefan, N., Vozarova, B., Del Parigi, A., Ossowski, V., Thompson, D. B., Hanson, R. L., Ravussin, E., Tataranni, P. A. (2002) The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. Int. J. Obes. Relat. Metab. Disord. 26, 1629-1632. <https://doi.org/10.1038/sj.ijo.0802161>
35. Tajmir, P., Ceddia, R. B., Li, R. K., Coe, I. R., Sweeney, G. (2004) Leptin increases cardiomyocyte hyperplasia via extracellular signal­regulated kinaseand phosphatidylinositol 3-kinase-dependent signaling pathways. Endocrinology 145, 1550­1555. <https://doi.org/10.1210/en.2003-1128>
36. Tune, J. D., Considine, R. V. (2007) Effects of leptin on cardiovascular physiology. J. Am. Soc. Hypertens. 1, 231-241. <https://doi.org/10.1016/j.jash.2007.04.001>
37. Umemoto, Y., Tsuji, K., Yang, F. C., Ebihara, Y., Kaneko, A., Furukawa, S., Nakahata, T. (1997) Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells. Blood 90, 3438-3443. <https://doi.org/10.1182/blood.V90.9.3438>
38. van der Vleuten, G. M., Kluijtmans, L. A., Hijmans, A., Blom, H. J., Stalenhoef, A. F., de Graaf, J. (2006) The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia. Int. J. Obes. (Lond) 30, 892-898. <https://doi.org/10.1038/sj.ijo.0803234>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive