Fol. Biol. 2014, 60, 133-143
https://doi.org/10.14712/fb2014060030133
HNF-4α Regulates Expression of Human Ornithin Carbamoyltransferase through Interaction with Two Positive Cis-Acting Regulatory Elements Located in the Proximal Promoter
References
1. 2001) Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer. J. Cell. Physiol. 188, 143-160.
< , A. R., Black, J. D., Azizkhan-Clifford, J. (https://doi.org/10.1002/jcp.1111>
2. Brusilow, S. W., Horwich, A. L. (1995) Urea cycle enzymes. In The Molecular and Metabolic Bases of Inherited Disease, eds. R. Scriver, A. L. Beaudet, W. S. Sly, D. Valle, pp. 1187-1232, McGraw-Hill, New York.
3. 1996) Human hepatocyte nucler factor 4 isoforms are encoded by distinct and differentially expressed genes. Mol. Cell. Biol. 16, 925-31.
< , T., Senkel, S., Holewa, B., Ryffel, G. U. (https://doi.org/10.1128/MCB.16.3.925>
4. 2012) Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors. Nucleic Acids Res. 40, 5343-5356.
< , B., Mane-Padros, D., Bolotin, E., Jiang, T., Sladek, F. M. (https://doi.org/10.1093/nar/gks190>
5. 2004) Structure and mechanism of the RNA polymerase II transcription machinery. Nat. Struct. Mol. Biol. 11, 394-403.
< , S. (https://doi.org/10.1038/nsmb763>
6. 1988) Immunocytochemical localization of ornithine transcarbamylase in rat intestinal mucosa. Light and electron microscopic study. J. Histochem. Cytochem. 36, 29-35.
< , Y., Kodama, H., Yanagisawa, M., Haraguchi, Y., Mori, M., Yokota, S. (https://doi.org/10.1177/36.1.3275711>
7. 1988) Structure of the human ornithine transcarbamylase gene. J. Biochem. 103, 302-308.
< , A., Tsuzuki, T., Shimada, K., Takiguchi, M., Mori, M., Matsuda, I. (https://doi.org/10.1093/oxfordjournals.jbchem.a122265>
8. 1984) Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase. Science 224, 1068-1074.
< , A. L., Fenton, W. A., Williams, K. R., Kalousek, F., Kraus, J. P., Doolittle, R. F., Konigsberg, W., Rosenberg, L. E. (https://doi.org/10.1126/science.6372096>
9. 2002) Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4α (HNF4α). J. Biol. Chem. 277, 25257-25265.
< , Y., Hayhurst, G. P., Inoue, J., Mori, M., Gonzalez, F. J. (https://doi.org/10.1074/jbc.M203126200>
10. 1990) Ectopic correction of ornithine transcarbamylase deficiency in sparse fur mice. J. Biol. Chem. 265, 14684-14690.
< , S. N., Grompe, M., Munir, M. I., Veres, G., Craigen, W. J., Caskey, C. T. (https://doi.org/10.1016/S0021-9258(18)77356-0>
11. 1993) Chicken ovalbumin upstream promoter-transcription factor (Coup-Tf) represses transcription from the promoter of the gene for ornithine transcarbamylase in a manner antagonistic to hepatocyte nuclear factor-IV (Hnf-4). J. Biol. Chem. 268, 11125-11133.
< , A., Nishiyori, A., Murakami, T., Tsukamoto, T., Hata, S., Osumi, T., Okamura, R., Mori, M., Takiguchi, M. (https://doi.org/10.1016/S0021-9258(18)82101-9>
12. 1984) Human ornithine transcarbamylase locus mapped to band Xp21.1 near the Duchenne muscular dystrophy locus. Science 226, 698-700.
< , V., de Martinville, B., Horwich, A. L., Rosenberg, L. E., Francke, U. (https://doi.org/10.1126/science.6494904>
13. 2010) Disruption of OTC promoter-enhancer interaction in a patient with symptoms of ornithine carbamoyltransferase deficiency. Hum. Mutat. 31, E1294-1303.
< , O., Jirsa, M., Eberova, J., Minks, J., Treslova, H., Bouckova, M., Storkanova, G., Vlaskova, H., Hrebicek, M., Dvorakova, L. (https://doi.org/10.1002/humu.21215>
14. 1996) TFIIB-directed transcriptional activation by the orphan nuclear receptor hepatocyte nuclear factor 4. Mol. Cell. Biol. 16, 1824-1831.
< , S., Karathanasis, S. K. (https://doi.org/10.1128/MCB.16.4.1824>
15. 1993) Orphan receptor Hnf-4 and Bzip protein C/Ebp-α bind to overlapping regions of the apolipoprotein-B gene promoter and synergistically activate transcription. J. Biol. Chem. 268, 16831-16838.
< , S., Halaas, J. L., Breslow, J. L., Sladek, F. M. (https://doi.org/10.1016/S0021-9258(19)85491-1>
16. 1988) Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Res. 16, 11057-11074.
< , N., Kadowaki, Y., Fukushige, S., Shimizu, S., Semba, K., Yamanashi, Y., Matsubara, K., Toyoshima, K., Yamamoto, T. (https://doi.org/10.1093/nar/16.23.11057>
17. 1990) Promoter and 11-kilobase upstream enhancer elements responsible for hepatoma cell-specific expression of the rat ornithine transcarbamylase gene. Mol. Cell. Biol. 10, 1180-1191.
, T., Nishiyori, A., Takiguchi, M., Mori, M. (
18. 1998) RNA polymerase II holoenzymes and subcomplexes. J. Biol. Chem. 273, 27757-27760.
< , V. E., Young, R. A. (https://doi.org/10.1074/jbc.273.43.27757>
19. 1998) Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements. Nucleic Acids Res. 26, 2491-2499.
< , H., Bhat-Nakshatri, P. (https://doi.org/10.1093/nar/26.10.2491>
20. 1994) Determination of tissue specificity of the enhancer by combinatorial operation of tissue-enriched transcription factors. Both HNF-4 and C/EBP ß are required for liver-specific activity of the ornithine transcarbamylase enhancer. J. Biol. Chem. 269, 1323-1331.
< , A., Tashiro, H., Kimura, A., Akagi, K., Yamamura, K., Mori, M., Takiguchi, M. (https://doi.org/10.1016/S0021-9258(17)42261-7>
21. 1985) Expression of nuclear genes encoding the urea cycle enzymes, carbamoyl-phosphate synthetase I and ornithine carbamoyl transferase, in rat liver and intestinal mucosa. Eur. J. Biochem. 152, 287-292
< , J., Nguyen, M., Bendayan, M., Shore, G. C. (https://doi.org/10.1111/j.1432-1033.1985.tb09196.x>
22. 1998) Oestrogen receptor facilitates the formation of preinitiation complex assembly: involvement of the general transcription factor TFIIB. Biochem. J. 336, 639-646.
< , M., Kang, K. I., Tora, L., Redeuilh, G. (https://doi.org/10.1042/bj3360639>
23. 2013) Ornithine carbamoyltransferase deficiency: molecular characterization of 29 families. Clin. Genet. 84, 552-559.
< , G., Vlaskova, H., Chuzhanova, N., Zeman, J., Stranecky, V., Majer, F., Peskova, K., Luksan, O., Jirsa, M., Hrebicek, M., Dvorakova, L. (https://doi.org/10.1111/cge.12085>
24. 2009) Proteomics reveals a physical and functional link between hepatocyte nuclear factor 4α and transcription factor IID. J. Biol. Chem. 284, 32405-32412.
< , H., Martin-Brown, S., Washburn, M. P., Florens, L., Conaway, J. W., Conaway, R. C. (https://doi.org/10.1074/jbc.M109.017954>
25. 2002) Mutations and polymorphisms in the human ornithine transcarbamylase gene. Hum. Mutat. 19, 93-107.
< , M., Jaleel, N., Morizono, H., Sheehy, L., Lynch, M. G. (https://doi.org/10.1002/humu.10035>
26. 2001) Nonradiochemical DNase I footprinting by capillary electrophoresis. Electrophoresis 22, 1979-1986.
< , D. O., Johnson, P., McCord, B. R. (https://doi.org/10.1002/1522-2683(200106)22:10<1979::AID-ELPS1979>3.0.CO;2-A>
27. 2006) Mutations and polymorphisms in the human ornithine transcarbamylase (OTC) gene. Hum. Mutat. 27, 626-632.
< , S., Brailey, L. L., Morizono, H., Bale, A. E., Tuchman, M. (https://doi.org/10.1002/humu.20339>
28. 2006) Identification of the DNA bases of a DNase I footprint by the use of dye primer sequencing on an automated capillary DNA analysis instrument. J. Biomol. Tech. 17, 103-113.
, M., Tessanne, K., Merighi, M., Laguna, R., Tabita, F. R. (