Fol. Biol. 2014, 60, 187-191

https://doi.org/10.14712/fb2014060040187

The Effect of MDMA-Induced Anxiety on Neuronal Apoptosis in Adult Male Rats' Hippocampus

S. Karimi, Mehrdad Jahanshahi, M. J. Golalipour

Department of Anatomy, Neuroscience Research Centre, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

Received October 2013
Accepted March 2014

References

1. Azami, A., Pasbakhsh, P., Akbari, M., Barbarestani, M., Ghahremani, M., Shokrgozar, M., et al. (2009) dual effects of 3,4-methylenedioxymethamphetamine (ecstasy) on survival and apoptosis of primary hippocampal neurons. Neural Regen. Res. 4, 1068-1072.
2. Bhattacharya, S. K., Bhattacharya, A., Ghosal, S. (1998) Anxiogenic activity of methylenedioxymethamphetamine (Ecstasy): an experimental study. Biogenic Amines 14, 217-237.
3. Capela, J. P., Carmo, H., Remião, F., Bastos, M. L., Meisel, A., Carvalho, F. (2009) Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview. Mol. Neurobiol. 39, 210-271. <https://doi.org/10.1007/s12035-009-8064-1>
4. Cho, K. O., Kim, S. K., Rhee, G. S., Kwack, S. J., Cho, D. H., Sung, K. W., Kim, S. y. (2007) Chronic 3,4-methylenedioxymethamphetamine treatment suppresses cell proliferation in the adult mouse dentate gyrus. Eur. J. Pharmacol. 566, 120-123. <https://doi.org/10.1016/j.ejphar.2007.04.008>
5. Cho, K. O., Rhee, G., Kwack, S., Chung, S., Kim, S. (2008) developmental exposure to 3,4-methylenedioxymethamphetamine results in downregulation of neurogenesis in the adult mouse hippocampus. Neuroscience 154, 1034-1041. <https://doi.org/10.1016/j.neuroscience.2008.04.040>
6. Cole, J. C., Sumnall, H. R. (2003) Altered states: the clinical effects of Ecstasy. Pharmacol. Ther. 98, 35-58. <https://doi.org/10.1016/S0163-7258(03)00003-2>
7. Fantegrossi, W. E., Ciullo, J. R., Wakabayashi, K. T., Garza, R. (2008) A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse. Neuroscience 151, 533-543. <https://doi.org/10.1016/j.neuroscience.2007.11.007>
8. Ferraz-de-Paula, V., Stankevicius, D., Ribeiro, A., Pinheiro, M., Rodrigues-Costa, E., Florio, J., Lapachinske, S. F., Moreau, R. L. M., Palermo-Neto, J. (2011) Differential behavioral outcomes of 3,4-methylenedioxymethamphetamine (MdMA-ecstasy) in anxiety-like responses in mice. Braz. J. Med. Biol. Res. 44, 428-437.
9. Green, A. R., Mechan, A. O., Elliott, J. M., O’Shea, E., Colado, M. I. (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MdMA, “ecstasy”). Pharmacol. Rev. 55, 463-508. <https://doi.org/10.1124/pr.55.3.3>
10. Gurtman, C. G., Morley, K. C., Li, K. M., Hunt, G. E., McGregor, I. S. (2002) Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion. Eur. J. Pharmacol. 446, 89-96. <https://doi.org/10.1016/S0014-2999(02)01820-4>
11. Handley, S. L., McBlane, J. W. (1993) An assessment of the elevated X-maze for studying anxiety and anxiety-modulating drugs. J. Pharmacol. Toxicol. Methods 29, 129-138. <https://doi.org/10.1016/1056-8719(93)90063-K>
12. Hernandez-Rabaza, V., Domínguez-Escrib, L., Barcia, J. A., Rosel, J. F., Romero, F. J., Garcia-Verdugo, J. M., Canales, J. J. (2006) Binge administration of 3,4-methylenedioxymethamphetamine (“ecstasy”) impairs the survival of neural precursors in adult rat dentate gyrus. Neuropharmacology 51, 967-973. <https://doi.org/10.1016/j.neuropharm.2006.06.019>
13. Ho, Y. J., Pawlak, C. R., Guo, L., Schwarting, R. K. W. (2004) Acute and long-term consequences of single MDMA administration in relation to individual anxiety levels in the rat. Behav. Brain Res. 149, 135-144. <https://doi.org/10.1016/S0166-4328(03)00220-1>
14. Jahanshahi, M., Sadeghi, Y., Hosseini, A. (2006) Estimation of astrocyte number in different subfield of rat hippocampus. Pak. J. Biol. Sci. 9, 1595-1597. <https://doi.org/10.3923/pjbs.2006.1595.1597>
15. Jahanshahi, M., Nickmahzar, E., Babakordi, F. (2013a) The effect of Ginkgo biloba extract on scopolamine-induced apoptosis in the hippocampus of rats. Anat. Sci. Int. 17, 1-6.
16. Jahanshahi, M., Nikmahzar, E. G., Babakordi, F., Khosravi, M., Seid-Hosseini, F. (2013b) Ecstasy, anxiety and rat hippocampal astrocytes. Eur. J. Anat. 17, 23-28.
17. Jiménez, A., Jordà, E. G., Verdaguer, E., Pubill, D., Sureda, F. X., Canudas, A. M., Escubedoa, E., Camarasaa, J., Caminsa, A., Pallàs, M. (2004) Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells. Toxicol. Appl. Pharmacol. 196, 223-234. <https://doi.org/10.1016/j.taap.2003.12.017>
18. Kalant, H. (2001) The pharmacology and toxicology of ‘ecstasy’ (MdMA) and related drugs. CMAJ 165, 917-928.
19. Kjelstrup, K. G., Tuvnes, F. A., Steffenach, H. A., Murison, R., Moser, E. I., Moser, M. B. (2002) Reduced fear expression after lesions of the ventral hippocampus. Proc. Natl. Acad. Sci. USA 99, 10825-10830. <https://doi.org/10.1073/pnas.152112399>
20. Knowles, W. D. (1992) Normal anatomy and neurophysiology of the hippocampal formation. J. Clin. Neurophysiol. 9, 253-263. <https://doi.org/10.1097/00004691-199204010-00006>
21. Kroemer, G., Martin, S. J. (2005) Caspase-independent cell death. Nat. Med. 11, 725-730. <https://doi.org/10.1038/nm1263>
22. Lin, H. Q., Burden, P. M., Christie, M. J., Johnston, G. A. R. (1999) The anxiogenic-like and anxiolytic-like effects of MdMA on mice in the elevated plus-maze: a comparison with amphetamine. Pharmacol. Biochem. Behav. 62, 403-408. <https://doi.org/10.1016/S0091-3057(98)00191-9>
23. McHugh, S. B., Deacon, R. M. J., Rawlins, J. N. P., Bannerman, D. M. (2004) Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety. Behav. Neurosci. 118, 63-78. <https://doi.org/10.1037/0735-7044.118.1.63>
24. Navarro, J. F., Maldonado, E. (2002) Acute and subchronic effects of MDMA. Prog. Neuropsychopharmacol. Biol. Psychiatry 26, 1151-1154. <https://doi.org/10.1016/S0278-5846(02)00250-6>
25. Palenicek, T., Votava, M., Bubenikova, V., Horacek, J. (2005) Increased sensitivity to the acute effects of MDMA. Physiol. Behav. 86, 546-553. <https://doi.org/10.1016/j.physbeh.2005.08.043>
26. Pellow, S., Chopin, P., File, S. E., Briley, M. (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods 14, 149-167. <https://doi.org/10.1016/0165-0270(85)90031-7>
27. Riezzo, I., Cerretani, D., Fiore, C., Bello, S., Centini, F., D’Errico, S., Fiaschi, A. I., Giorgi, G., Neri, M., Pomara, C., Turillazzi, E., Fineschi, V. (2010) Enzymatic-non- enzymatic cellular antioxidant defense systems response and immunohistochemical detection of MdMA, VMAT2, HSP70, and apoptosis as biomarkers for MdMA (ecstasy) neurotoxicity. J. Neurosci. Res. 88, 905-916. <https://doi.org/10.1002/jnr.22245>
28. Rodgers, R., Cole, J.(1994) The elevated plus-maze: pharmacology, methodology and ethology. In: Ethology and Psychopharmacology, eds. Coopper S. J., Hendrie C. A., pp. 9-43, John Wiley and Sons Ltd., New York
29. Rosene, D. L., Van Hoesen, G. W. (1987) The hippocampal formation of the primate brain. A review of some comparative aspects of cytoarchitecture and connections. Cereb. Cortex 6, 345-456. <https://doi.org/10.1007/978-1-4615-6616-8_9>
30. Stephan, H. (1983) Evolutionary trends in limbic structures. Neurosci. Biobehav. Rev. 7, 367-374. <https://doi.org/10.1016/0149-7634(83)90041-6>
31. Sveen, M. L., Knudsen, G. M., Aznar, S. (2004) No effect of MdMA (ecstasy) on cell death and 5-HT2A receptor density in organotypic rat hippocampal cultures. Neurosci. Lett. 362, 6-9. <https://doi.org/10.1016/j.neulet.2004.01.051>
32. Treit, D. (1985) Animal models for the study of anti-anxiety agents: a review. Neurosci. Biobehav. Rev. 9, 203-222. <https://doi.org/10.1016/0149-7634(85)90046-6>
33. Wang, X., Li, J., Zhu, S. P. (2007) Neuron apoptosis induced by 3,4-methylenedioxy methamphetamine and the expression of caspase-3. West China Journal of Pharmaceutical Sciences 22, 511.
34. Wang, X., Zhu, S. P., Kuang, W. H., Li, J., Sun, X., Huang, M. S., Sun, X. (2009) Neuron apoptosis induced by 3,4-methylenedioxy methamphetamine and expression of apoptosis-related factors in rat brain. Journal of Sichuan University. Medical science edition 40, 1000-1002, 1037.
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Archive