Fol. Biol. 2015, 61, 60-65

https://doi.org/10.14712/fb2015061020060

Subcellular Localization of Proteins Responding to Mitoxantrone-Induced DNA Damage in Leukaemic Cells

Jana Ćmielová, M. Lesná, M. Řezáčová

Department of Medical Biochemistry, Faculty of Medicine in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic

Received October 2014
Accepted November 2014

References

1. Bartek, J., Lukas J. (2003) Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3, 421-429. <https://doi.org/10.1016/S1535-6108(03)00110-7>
2. Brooks, C. L., Gu, W. (2003) Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr. Opin. Cell Biol. 15, 164-171. <https://doi.org/10.1016/S0955-0674(03)00003-6>
3. Chouinard, G., Clément, I., Lafontaine, J., Rodier, F., Schmitt, E. (2013) Cell cycle-dependent localization of CHK2 at centrosomes during mitosis. Cell Div. 8, 7. <https://doi.org/10.1186/1747-1028-8-7>
4. Cmielová, J., Rezáčová, M. (2011) p21Cip1/Waf1 protein and its function based on a subcellular localization [corrected]. J. Cell. Biochem. 112, 3502-3506. <https://doi.org/10.1002/jcb.23296>
5. Davis, J. R., Mossalam, M., Lim, C. S. (2013) Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2. Mol. Pharm. 10, 1340-1349. <https://doi.org/10.1021/mp300543t>
6. Eriksson, D., Stigbrand, T. (2010) Radiation-induced cell death mechanisms. Tumour Biol. 31, 363-372. <https://doi.org/10.1007/s13277-010-0042-8>
7. Lee, J. Y., Kim, H. S., Kim, J. Y., Sohn, J. (2009) Nuclear translocation of p21(WAF1/CIP1) protein prior to its cytosolic degradation by UV enhances DNA repair and survival. Biochem. Biophys. Res. Commun. 390, 1361-1366. <https://doi.org/10.1016/j.bbrc.2009.10.160>
8. Li, J., Stern, D. F. (2005) DNA damage regulates Chk2 association with chromatin. J. Biol. Chem. 280, 37948-37956. <https://doi.org/10.1074/jbc.M509299200>
9. Maki, C. G. (2010) P53 localization. Molecular Biology Intelligence Unit 1, 117-126. <https://doi.org/10.1007/978-1-4419-8231-5_8>
10. Mirzayans, R., Andrais, B., Scott, A., Murray, D. (2012) New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy. J. Biomed. Biotechnol. 2012:170325. <https://doi.org/10.1155/2012/170325>
11. O’Brate, A., Giannakakou, P. (2003) The importance of p53 location: nuclear or cytoplasmic zip code? Drug Resist. Updat. 6, 313-322. <https://doi.org/10.1016/j.drup.2003.10.004>
12. Qiu, R., Wang, S., Feng, X., Chen, F., Yang, K., He, S. (2011) Effect of subcellular localization of P21 on proliferation and apoptosis of HepG2 cells. J. Huazhong Univ. Sci. Technolog. Med. Sci. 31, 756-761. <https://doi.org/10.1007/s11596-011-0672-0>
13. Rashi-Elkeles, S., Elkon, R., Shavit, S., Lerenthal, Y., Linhart, C., Kupershtein, A., Amariglio, N., Rechavi, G., Shamir, R., Shiloh, Y. (2011) Transcriptional modulation induced by ionizing radiation: p53 remains a central player. Mol. Oncol. 5, 336-348. <https://doi.org/10.1016/j.molonc.2011.06.004>
14. Reinhardt, H. C., Yaffe, M. B. (2009) Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr. Opin. Cell. Biol. 21, 245-255. <https://doi.org/10.1016/j.ceb.2009.01.018>
15. Ryan, K. M., Phillips, A. C., Vousden, K. H. (2001) Regulation and function of the p53 tumor suppressor protein. Curr. Opin. Cell. Biol. 13, 332-327. <https://doi.org/10.1016/S0955-0674(00)00216-7>
16. Seifrtová, M., Havelek, R., Chmelařová, M., Ćmielová, J., Muthná, D., Stoklasová, A., Zemánková, S., Řezáčová, M. (2011) The effect of ATM and ERK1/2 inhibition on mitoxantrone- induced cell death of leukaemic cells. Folia Biol. (Praha) 57, 74-81.
17. Solozobova, V., Rolletschek, A., Blattner, C. (2009) Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage. BMC Cell. Biol. 10, 46. <https://doi.org/10.1186/1471-2121-10-46>
18. Stracker, T. H., Usui, T., Petrini, J. H. (2009) Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst.) 8, 1047-1054. <https://doi.org/10.1016/j.dnarep.2009.04.012>
19. Xiong, Y. (2010) Targeting p21 degradation locally. Dev. Cell 19, 641-643. <https://doi.org/10.1016/j.devcel.2010.10.020>
20. Zhao, T., Xu, Y. (2010) p53 and stem cells: new developments and new concerns. Trends Cell. Biol. 20, 170-175. <https://doi.org/10.1016/j.tcb.2009.12.004>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive