Fol. Biol. 2016, 62, 131-137

https://doi.org/10.14712/fb2016062030131

Down-regulation of AQP4 Inhibits Proliferation, Migration and Invasion of Human Breast Cancer Cells

Y.-B. Li1, Sheng-Rong Sun1, X.-H. Han2

1Renmin Hospital of Wuhan University, Wuhan, China
2Inner Mongolia People’s Hospital, Hohhot, China

Received September 2015
Accepted November 2015

References

1. Agre, P., Sasaki, S., Chrispeels, M. J. (1993) Aquaporins: a family of water channel proteins. Am. J. Physiol. 265, F461.
2. Agre, P., King, L. S., Yasui, M., Guggino, W. B., Ottersen, O. P., Fujiyoshi, Y., Engel, A., Nielsen, S. (2002) Aquaporin water channels – from atomic structure to clinical medicine. J. Physiol. 542, 3-16. <https://doi.org/10.1113/jphysiol.2002.020818>
3. Amos, S., Mut, M., diPierro, C. G., Carpenter, J. E., Xiao, A., Kohutek, Z. A., Redpath, G. T., Zhao, Y., Wang, J., Shaffrey, M. E., Hussaini, I. M. (2007) Protein kinase C-α- mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion. Cancer Res. 67, 10241-10251. <https://doi.org/10.1158/0008-5472.CAN-07-0030>
4. Birchmeier, W., Behrens, J. (1994) Cadherin expression in carcinomas: role in the formation of cell-junctions and the prevention of invasiveness. Biochim. Biophys. Acta 1198, 11-26.
5. Choi, J. H., Wu, H. G., Jung, K. C., Lee, S. H., Kwon, E. K. (2009) Apoptosis and expression of AQP5 and TGF-β in the irradiated rat submandibular gland. Cancer Res. Treat. 41, 145-154. <https://doi.org/10.4143/crt.2009.41.3.145>
6. Flamenco, P., Galizia, L., Rivarola, V., Fernandez, J., Ford, P., Capurro, C. (2009) Role of AQP2 during apoptosis in cortical collecting duct cells. Biol. Cell 101, 237-250. <https://doi.org/10.1042/BC20080050>
7. Hsu, Y. L., Huang, M. S., Yang, C. J., Hung, J. Y., Wu, L. Y., Kuo, P. L. (2011) Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelialto-mesenchymal transition of cancer by Runx2/Snail signaling pathway. J. Biol. Chem. 286, 37335-37346. <https://doi.org/10.1074/jbc.M111.256156>
8. Jeanes, A., Gottardi, C. J., Yap, A. S. (2008) Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene 27, 6920-6929. <https://doi.org/10.1038/onc.2008.343>
9. Kong, H., Fan, Y., Xie, J., Ding, J., Sha, L., Shi, X., Sun, X., Hu, G. (2008) AQP4 knockout impairs proliferation, migration and neuronal differentiation of adult neural stem cells. J. Cell Sci. 121, 4029-4036. <https://doi.org/10.1242/jcs.035758>
10. Maki, M., Kobayashi, T., Terao, T., Ikenoue, T., Satoh, K., Nakabayashi, M., Sagara, Y., Kajiwara, Y., Urata, M., Grp, B. S. (2000) Antithrombin therapy for severe preeclampsia: results of a double-blind, randomized, placebo-controlled trial. Thromb. Haemost. 84, 583-590. <https://doi.org/10.1055/s-0037-1614071>
11. Nollet, F., Berx, G, van Roy, F. (1999) The role of the E-cadherin/ catenin adhesion complex in the development and progression of cancer. Mol. Cell Biol. Res. Commun. 2, 77-85. <https://doi.org/10.1006/mcbr.1999.0155>
12. Onder, T. T., Gupta, P. B, Mani, S. A, Yang, J., Lander, E. S., Weinberg, R. A. (2008) Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 68, 3645-3654. <https://doi.org/10.1158/0008-5472.CAN-07-2938>
13. Papadopoulos, M. C., Saadoun, S., Verkman, A. S. (2008) Aquaporins and cell migration. Pflugers Arch. 456, 693-700. <https://doi.org/10.1007/s00424-007-0357-5>
14. Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R. A., Ginsberg, M. H., Borisy, G., Parsons, J. T., Horwitz, A. R. (2003) Cell migration: integrating signals from front to back. Science 302, 1704-1709. <https://doi.org/10.1126/science.1092053>
15. Shi, Z., Zhang, T., Luo, L., Zhao, H., Cheng, J., Xiang, J., Zhao, C. (2012) Aquaporins in human breast cancer: identification and involvement in carcinogenesis of breast cancer. J. Surg. Oncol. 106, 267-272. <https://doi.org/10.1002/jso.22155>
16. Siegel, R., Ma, J., Zou, Z., Jemal, A. (2014) Cancer statistics, 2014. CA Cancer J. Clin. 64, 9-29. <https://doi.org/10.3322/caac.21208>
17. Soto, E., Yanagisawa, M., Marlow, L. A., Copland, J. A., Perez, E. A., Anastasiadis, P. Z. (2008) p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression. J. Cell Biol. 183, 737-749. <https://doi.org/10.1083/jcb.200805113>
18. Stockinger, A., Eger, A., Wolf, J., Beug, H., Foisner, R. (2001) E-cadherin regulates cell growth by modulating proliferation- dependent β-catenin transcriptional activity. J. Cell Biol. 154, 1185-1196. <https://doi.org/10.1083/jcb.200104036>
19. Tang, Y. P., Su, J. J., Ding, H. Y., Dong, Q. A. (2011) Relationship between AQP4 and brain edema, cells death and apoptosis following intracerebral hemorrhage. Neurology 76, A448-A449.
20. Thiery, J. P. (2002) Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2, 442-454. <https://doi.org/10.1038/nrc822>
21. Verkman, A. S., Hara-Chikuma, M., Papadopoulos, M. C. (2008) Aquaporins – new players in cancer biology. J. Mol. Med. (Berl) 86, 523-529. <https://doi.org/10.1007/s00109-008-0303-9>
22. Warth, A., Kroger, S., Wolburg, H. (2004) Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae. Acta Neuropathol. 107, 311-318.
23. Xie, H. F., Liu, F. F., Liu, L. S., Dan, J., Luo, Y., Yi, Y. X., Chen, X., Li, J. (2013) Protective role of AQP3 in UVAinduced NHSFs apoptosis via Bcl2 up-regulation. Arch. Dermatol. Res. 305, 397-406. <https://doi.org/10.1007/s00403-013-1324-y>
24. Xie, Y. P., Wen, X. H., Jiang, Z. Q., Fu, H. Q., Han, H., Dai, L. C. (2012) Aquaporin 1 and aquaporin 4 are involved in invasion of lung cancer cells. Clin. Lab. 58, 75-80.
25. Yanagisawa, M., Anastasiadis, P. Z. (2006) p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness. J. Cell Biol. 174, 1087-1096. <https://doi.org/10.1083/jcb.200605022>
26. Zhang, H. M., Li, L., Papadopoulou, N., Hodgson, G., Evans, E., Galbraith, M., Dear, M., Vougier, S., Saxton, J., Shaw, P. E. (2008) Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1. Nucleic Acids Res. 36, 2594-2607. <https://doi.org/10.1093/nar/gkn099>
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