Fol. Biol. 2017, 63, 31-34

https://doi.org/10.14712/fb2017063010031

The Influence of Sodium Fluoride on the Growth of Ameloblasts and Kidney Proximal Tubular Cells

Soegeng Wahluyo1, K. Ismiyatin2, B. Purwanto3, I. S. Mukono4

1Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Airlangga, Surabaya, Indonesia
2Department of Conservative Dentistry, Faculty of Dentistry, Universitas Airlangga, Surabaya, Indonesia
3Department of Physiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
4Department of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Received May 2016
Accepted August 2016

Fluoride has toxic potential particularly for teeth, bones, and kidney. This study was aimed to investigate the NaF exposure effects on the growth of ameloblasts and kidney proximal tubular cells. Adult male healthy rats were used as experiment models, divided into control and NaF-induced groups. The expression of amelogenin, Bcl-2, and caspase-3 were significantly different in the control and NaF-induced group (P < 0.05). There was no correlation among these proteins in the control group but significant correlation in the NaF-induced group (r = 0.694). There was a significant correlation in proximal tubular cells, as seen from the increase of caspase-3 in the NaF-induced group (r = 0.715).

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