<i>KCNJ11</i> and <i>KCNQ1</i> Gene Polymorphisms Are Not Associated with Post-Transplant Diabetes Mellitus in Kidney Allograft Recipients Treated with Tacrolimus

Dabrowska-Zamojcin, E.; Tarnowski, M.; Szydłowski, M.; Romanowski, M.; Dziedziejko, V.; Safranow, K.; Domanski, L.; Pawlik, Andrzej

doi:10.14712/fb2017063030115

Folia Biologica > Archive > 2017, Vol. 63 > Issue 3 > KCNJ11 and KCNQ1 Gene…

Fol. Biol. 2017, 63, 115-119

https://doi.org/10.14712/fb2017063030115

KCNJ11 and KCNQ1 Gene Polymorphisms Are Not Associated with Post-Transplant Diabetes Mellitus in Kidney Allograft Recipients Treated with Tacrolimus

E. Dabrowska-Zamojcin¹, M. Tarnowski², M. Szydłowski², M. Romanowski³, V. Dziedziejko⁴, K. Safranow⁴, L. Domanski⁵, Andrzej Pawlik²

¹Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
²Department of Physiology, Pomeranian Medical University, Szczecin, Poland
³Department of General and Transplantation Surgery, Pomeranian Medical University, Szczecin, Poland
⁴Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
⁵Department of Nephrology and Transplantology, Pomeranian Medical University, Szczecin, Poland

Received February 2017
Accepted April 2017

Post-transplant diabetes mellitus (PTDM) is a metabolic disorder occurring after solid organ transplantation during the therapy with calcineurin inhibitors. ATP-sensitive potassium channels KCNJ11 and KCNQ1 play an important role in the regulation of insulin secretion by β cells and development of diabetes mellitus. Numerous studies have confirmed the association between KCNJ11 and KCNQ1 gene polymorphisms and type 2 diabetes. The aim of this study was to examine the association between KCNJ11 and KCNQ1 gene polymorphisms and posttransplant diabetes mellitus in kidney allograft recipients treated with tacrolimus. The study included 201 patients who received kidney transplants. The patients were subdivided into two subgroups: patients with PTDM (N = 35) and patients without PTDM (N = 166). The association between KCNJ11 and KCNQ1 gene polymorphisms and post-transplant diabetes was studied in three models of univariate Cox regression analysis, i.e., additive, dominant and recessive. In these three models there were no statistically significant associations between KCNJ11 and KCNQ1 gene polymorphisms and PTDM. The results of this study suggest lack of association between KCNJ11 and KCNQ1 gene polymorphisms and post-transplant diabetes mellitus in kidney allograft recipients treated with tacrolimus in the Polish population.