Fol. Biol. 2018, 64, 10-15

https://doi.org/10.14712/fb2018064010010

Extracellular DNA as a Prognostic and Therapeutic Target in Mouse Colitis under DNase I Treatment

J. Bábíčková1,2, J. Čonka2, L. Janovičová2, M. Boriš3, B. Konečná2, Roman Gardlík2

1Department of Clinical Medicine, University of Bergen, Bergen, Norway
2Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
3Institute of Electronics and Photonics, Faculty of Electrical Engineering and Information Technology, Slovak University of Technology, Bratislava, Slovakia

Received December 2017
Accepted March 2018

References

1. Antonatos, D., Patsilinakos, S., Spanodimos, S., Korkonikitas, P., Tsigas, D. (2006) Cell-free DNA levels as a prognostic marker in acute myocardial infarction. Ann. N. Y. Acad. Sci. 1075, 278-281. <https://doi.org/10.1196/annals.1368.037>
2. Babickova, J., Tothova, L., Lengyelova, E., Bartonova, A., Hodosy, J., Gardlik, R., Celec, P. (2015) Sex differences in experimentally induced colitis in mice: a role for estrogens. Inflammation 38, 1996-2006. <https://doi.org/10.1007/s10753-015-0180-7>
3. Bennike, T. B., Carlsen, T. G., Ellingsen, T., Bonderup, O. K., Glerup, H., Bogsted, M., Christiansen, G., Birkelund, S., Stensballe, A., Andersen, V. (2015) Neutrophil extracellular traps in ulcerative colitis: a proteome analysis of intestinal biopsies. Inflamm. Bowel Dis. 21, 2052-2067. <https://doi.org/10.1097/MIB.0000000000000460>
4. Boyko, M., Ohayon, S., Goldsmith, T., Douvdevani, A., Gruenbaum, B. F., Melamed, I., Knyazer, B., Shapira, Y., Teichberg, V. I., Elir, A., Klein, M., Zlotnik, A. (2011) Cellfree DNA – a marker to predict ischemic brain damage in a rat stroke experimental model. J. Neurosurg. Anesthesiol. 23, 222-228. <https://doi.org/10.1097/ANA.0b013e31821b536a>
5. Brill, A., Fuchs, T. A., Savchenko, A. S., Thomas, G. M., Martinod, K., De Meyer, S. F., Bhandari, A. A., Wagner, D. D. (2012) Neutrophil extracellular traps promote deep vein thrombosis in mice. J. Thromb. Haemost. 10, 136-144. <https://doi.org/10.1111/j.1538-7836.2011.04544.x>
6. Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., Zychlinsky, A. (2004) Neutrophil extracellular traps kill bacteria. Science 303, 1532-1535. <https://doi.org/10.1126/science.1092385>
7. Caudrillier, A., Kessenbrock, K., Gilliss, B. M., Nguyen, J. X., Marques, M. B., Monestier, M., Toy, P., Werb, Z., Looney, M. R. (2012) Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J. Clin. Invest. 122, 2661-2671. <https://doi.org/10.1172/JCI61303>
8. Chiu, T. W., Young, R., Chan, L. Y., Burd, A., Lo, D. Y. (2006) Plasma cell-free DNA as an indicator of severity of injury in burn patients. Clin. Chem. Lab. Med. 44, 13-17. <https://doi.org/10.1515/CCLM.2006.003>
9. Destouni, A., Vrettou, C., Antonatos, D., Chouliaras, G., Traeger- Synodinos, J., Patsilinakos, S., Kitsiou-Tzeli, S., Tsigas, D., Kanavakis, E. (2009) Cell-free DNA levels in acute myocardial infarction patients during hospitalization. Acta Cardiol. 64, 51-57. <https://doi.org/10.2143/AC.64.1.2034362>
10. Halverson, T. W., Wilton, M., Poon, K. K., Petri, B., Lewenza, S. (2015) DNA is an antimicrobial component of neutrophil extracellular traps. PLoS Pathog. 11, e1004593. <https://doi.org/10.1371/journal.ppat.1004593>
11. Jiang, P., Chan, C. W., Chan, K. C., Cheng, S. H., Wong, J., Wong, V. W., Wong, G. L., Chan, S. L., Mok, T. S., Chan, H. L., Lai, P. B., Chiu, R. W., Lo, Y. M. (2015) Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients. Proc. Natl. Acad. Sci. USA 112, E1317-1325.
12. Kim, J. J., Shajib, M. S., Manocha, M. M., Khan, W. I. (2012) Investigating intestinal inflammation in DSS-induced model of IBD. J. Vis. Exp. 60, pii: 3678.
13. Koike, Y., Uchida, K., Tanaka, K., Ide, S., Otake, K., Okita, Y., Inoue, M., Araki, T., Mizoguchi, A., Kusunoki, M. (2014) Dynamic pathology for circulating free DNA in a dextran sodium sulfate colitis mouse model. Pediatr. Surg. Int. 30, 1199-1206. <https://doi.org/10.1007/s00383-014-3607-6>
14. Krieg, A. M. (2002) CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760. <https://doi.org/10.1146/annurev.immunol.20.100301.064842>
15. Laukova, L., Konecna, B., Babickova, J., Wagnerova, A., Meliskova, V., Vlkova, B., Celec, P. (2017) Exogenous deoxyribonuclease has a protective effect in a mouse model of sepsis. Biomed. Pharmacother. 93, 8-16. <https://doi.org/10.1016/j.biopha.2017.06.009>
16. Lo, Y. M., Zhang, J., Leung, T. N., Lau, T. K., Chang, A. M., Hjelm, N. M. (1999) Rapid clearance of fetal DNA from maternal plasma. Am. J. Hum. Genet. 64, 218-224. <https://doi.org/10.1086/302205>
17. Lui, Y. Y., Woo, K. S., Wang, A. Y., Yeung, C. K., Li, P. K., Chau, E., Ruygrok, P., Lo, Y. M. (2003) Origin of plasma cell-free DNA after solid organ transplantation. Clin. Chem. 49, 495-496. <https://doi.org/10.1373/49.3.495>
18. Luo, L., Zhang, S., Wang, Y., Rahman, M., Syk, I., Zhang, E., Thorlacius, H. (2014) Proinflammatory role of neutrophil extracellular traps in abdominal sepsis. Am. J. Physiol. Lung Cell. Mol. Physiol. 307, L586-596. <https://doi.org/10.1152/ajplung.00365.2013>
19. Mai, S. H., Khan, M., Dwivedi, D. J., Ross, C. A., Zhou, J., Gould, T. J., Gross, P. L., Weitz, J. I., Fox-Robichaud, A. E., Liaw, P. C., on behalf of the Canadian Critical Care Translational Biology G (2015) Delayed but not early treatment with DNase reduces organ damage and improves outcome in a murine model of sepsis. Shock 44, 166-172. <https://doi.org/10.1097/SHK.0000000000000396>
20. Malickova, K., Duricova, D., Bortlik, M., Hruskova, Z., Svobodova, B., Machkova, N., Komarek, V., Fucikova, T., Janatkova, I., Zima, T., Lukas, M. (2011) Impaired deoxyribonuclease I activity in patients with inflammatory bowel diseases. Autoimmune Dis. 2011, 945861.
21. Masuda, S., Nakazawa, D., Shida, H., Miyoshi, A., Kusunoki, Y., Tomaru, U., Ishizu, A. (2016) NETosis markers: quest for specific, objective, and quantitative markers. Clin. Chim. Acta 459, 89-93. <https://doi.org/10.1016/j.cca.2016.05.029>
22. O’Driscoll, L. (2007) Extracellular nucleic acids and their potential as diagnostic, prognostic and predictive biomarkers. Anticancer Res. 27, 1257-1265.
23. Palffy, R., Gardlik, R., Behuliak, M., Jani, P., Balakova, D., Kadasi, L., Turna, J., Celec, P. (2011) Salmonella-mediated gene therapy in experimental colitis in mice. Exp. Biol. Med. (Maywood) 236, 177-183. <https://doi.org/10.1258/ebm.2010.010277>
24. Park, J., Wysocki, R. W., Amoozgar, Z., Maiorino, L., Fein, M. R., Jorns, J., Schott, A. F., Kinugasa-Katayama, Y., Lee, Y., Won, N. H., Nakasone, E. S., Hearn, S. A., Kuttner, V., Qiu, J., Almeida, A. S., Perurena, N., Kessenbrock, K., Goldberg, M. S., Egeblad, M. (2016) Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci. Transl. Med. 8, 361ra138.
25. Patutina, O. A., Mironova, N. L., Ryabchikova, E. I., Popova, N. A., Nikolin, V. P., Kaledin, V. I., Vlassov, V. V., Zenkova, M. A. (2010) Tumoricidal activity of RNase A and DNase I. Acta Naturae 2, 88-94. <https://doi.org/10.32607/20758251-2010-2-1-88-93>
26. Peer, V., Abu Hamad, R., Berman, S., Efrati, S. (2016) Renoprotective effects of DNAse-I treatment in a rat model of ischemia/reperfusion-induced acute kidney injury. Am. J. Nephrol. 43, 195-205. <https://doi.org/10.1159/000445546>
27. Sartor, R. B. (2006) Mechanisms of disease: pathogenesis of Crohn’s disease and ulcerative colitis. Nat. Clin. Pract. Gastroenterol. Hepatol. 3, 390-407. <https://doi.org/10.1038/ncpgasthep0528>
28. Savchenko, A. S., Borissoff, J. I., Martinod, K., De Meyer, S. F., Gallant, M., Erpenbeck, L., Brill, A., Wang, Y., Wagner, D. D. (2014) VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Blood 123, 141-148. <https://doi.org/10.1182/blood-2013-07-514992>
29. Shoham, Y., Krieger, Y., Perry, Z. H., Shaked, G., Bogdanov- Berezovsky, A., Silberstein, E., Sagi, A., Douvdevani, A. (2014) Admission cell free DNA as a prognostic factor in burns: quantification by use of a direct rapid fluorometric technique. Biomed. Res. Int. 2014, 306580. <https://doi.org/10.1155/2014/306580>
30. Trejo-Becerril, C., Perez-Cardenas, E., Gutierrez-Diaz, B., De La Cruz-Siguenza, D., Taja-Chayeb, L., Gonzalez-Ballesteros, M., Garcia-Lopez, P., Chanona, J., Duenas-Gonzalez, A. (2016) Antitumor effects of systemic DNAse I and proteases in an in vivo model. Integr. Cancer Ther. 15, NP35-NP43. <https://doi.org/10.1177/1534735416631102>
31. Tsui, N. B., Jiang, P., Chow, K. C., Su, X., Leung, T. Y., Sun, H., Chan, K. C., Chiu, R. W., Lo, Y. M. (2012) High resolution size analysis of fetal DNA in the urine of pregnant women by paired-end massively parallel sequencing. PLoS One 7, e48319. <https://doi.org/10.1371/journal.pone.0048319>
32. Vokalova, L., Laukova, L., Conka, J., Meliskova, V., Borbelyova, V., Babickova, J., Tothova, L., Hodosy, J., Vlkova, B., Celec, P. (2017) Deoxyribonuclease partially ameliorates thioacetamide-induced hepatorenal injury. Am. J. Physiol. Gastrointest. Liver Physiol. 312, G457-G463. <https://doi.org/10.1152/ajpgi.00446.2016>
33. Wen, F., Shen, A., Choi, A., Gerner, E. W., Shi, J. (2013) Extracellular DNA in pancreatic cancer promotes cell invasion and metastasis. Cancer Res. 73, 4256-4266. <https://doi.org/10.1158/0008-5472.CAN-12-3287>
34. Zhong, X. Y., Burk, M. R., Troeger, C., Kang, A., Holzgreve, W., Hahn, S. (2000) Fluctuation of maternal and foetal free extracellular circulatory DNA in maternal plasma. Obstet. Gynecol. 96, 991-996.
35. Zinkova, A., Brynychova, I., Svacina, A., Jirkovska, M., Korabecna, M. (2017) Cell-free DNA from human plasma and serum differs in content of telomeric sequences and its ability to promote immune response. Sci. Rep. 7, 2591. <https://doi.org/10.1038/s41598-017-02905-8>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive