<i>Nos3</i> Gene Rs1799983 and Rs2070744 Polymorphisms in Patients with Periodontal Disease

Mazurek-Mochol, M.; Kozak, M.; Sawczuk, M.; Maciejewska, A.; Malinowski, D.; Safranow, K.; Pawlik, Andrzej

doi:10.14712/fb2018064020059

Folia Biologica > Archive > 2018, Vol. 64 > Issue 2 > Nos3 Gene Rs1799983 and Rs2070744…

Fol. Biol. 2018, 64, 59-64

https://doi.org/10.14712/fb2018064020059

Nos3 Gene Rs1799983 and Rs2070744 Polymorphisms in Patients with Periodontal Disease

M. Mazurek-Mochol¹, M. Kozak², M. Sawczuk³, A. Maciejewska³, D. Malinowski⁴, K. Safranow⁵, Andrzej Pawlik⁶

¹Department of Periodontology, Pomeranian Medical University, Szczecin, Poland
²Department of Prosthetics, Pomeranian Medical University, Szczecin, Poland
³Department Faculty of Physical Education and Health Promotion, University of Szczecin, Szczecin, Poland
⁴Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
⁵Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
⁶Department of Physiology, Pomeranian Medical University, Szczecin, Poland

Received January 2018
Accepted May 2018

Periodontal disease is a common oral disease. Inflammatory and immune responses to oral microorganisms initiate the development of periodontitis. Cigarette smoking is an important environmental risk factor for periodontitis. Another important inflammatory mediator is nitric oxide (NO). NO modulates vascular tone, microvascular permeability, leukocyte migration and oxidative activity, contributing to the direct killing of microorganisms. Several polymorphisms of the NOS3 gene have been detected, which may alter gene expression and NO synthesis. The aim of this study was to examine the association between the NOS3 rs1799983 and rs2070744 polymorphisms and periodontal disease. This study enrolled 200 patients with periodontal diseases (130 were non-smokers and 70 were smokers) and 160 control subjects (126 were non-smokers and 34 were smokers). Among the patients with periodontal disease, we observed a statistically increased frequency of patients with the CT genotype (TC vs. TT; 95%CI 1.83, OR 1.16–2.88, P = 0.011). There was a statistically significant increased frequency of CT genotype carriers among non-smoking patients with periodontal disease as compared with non-smoking controls, whereas there were no statistically significant differences between smoking patients with periodontal disease and smoking control subjects. The results of our study suggest an association between the NOS3 rs2070744 polymorphism and periodontal disease.