Fol. Biol. 2018, 64, 97-102

https://doi.org/10.14712/fb2018064030097

Serum Levels of Aryl Hydrocarbon Receptor, Cytochromes P450 1A1 and 1B1 in Patients with Exacerbated Psoriasis Vulgaris

Martin Beránek1,2, Z. Fiala3, J. Kremláček4, C. Andrýs5, J. Krejsek5, K. Hamáková6, V. Palička2, L. Borská4

1Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic
2Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Králové and Faculty of Medicine in Hradec Králové, Charles University, Czech Republic
3Institute of Hygiene and Preventive Medicine, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic
4Institute of Pathological Physiology, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic
5Institute of Clinical Immunology and Allergology, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic
6Clinic of Dermal and Venereal Diseases, University Hospital Hradec Králové, Czech Republic

Received April 2018
Accepted June 2018

The aryl hydrocarbon receptor (AhR) is highly expressed in psoriasis skin lesions. The aim of this study was to investigate serum concentrations of AhR, cytochromes P450 (CYP) 1A1 and 1B1 in patients with exacerbated psoriasis vulgaris treated with combined therapy of ultraviolet radiation (UVR) and crude coal tar. The analyses were performed by using enzyme-linked immunosorbent assays. Before the treatment, the patients had significantly higher serum levels of AhR and CYP1A1 than healthy controls. AhR median noticeably decreased after the therapy; nevertheless, it remained significantly higher compared to the controls. CYP1A1 levels measured before and after the therapy did not differ significantly. Serum CYP1A1 positively correlated with AhR values before and after the treatment. The serum values of CYP1B1 were very low and we did not see any differences between the study group and the control group. The study demonstrated that serum levels of AhR and CYP1A1 could indicate their immunopathological and metabolic roles in exacerbated psoriasis.

Funding

This study was supported by the projects PROGRES Q40-09, Q40-10 and Q40-11 of Charles University, Faculty of Medicine in Hradec Králové, Czech Republic.

References

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