Fol. Biol. 2018, 64, 167-172

https://doi.org/10.14712/fb2018064050167

Extracellular DNA is Increased in Dextran Sulphate Sodium-Induced Colitis in Mice

M. Maronek1, B. Gromova1, R. Liptak1, D. Klimova2, B. Cechova1, Roman Gardlík1

1Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic
2Cancer Research Institute of the Slovak Academy of Sciences, Bratislava, Slovak Republic

Received August 2018
Accepted December 2018

References

1. Ahmed, A., Soliman, R., Samir, S. (2016) Cell free DNA and procalcitonin as early markers of complications in ICU patients with multiple trauma and major surgery. Clin. Lab. 62, 2395-2404.
2. Bábíčková J., Čonka, J., Janovičová L., Boris, M., Konečná, B., Gardlík, R. (2018) Extracellular DNA as a prognostic and therapeutic target in mouse colitis under DNase I treatment. Folia Biol. (Praha) 64, 10-15. <https://doi.org/10.14712/fb2018064010010>
3. Clementi, A., Virzi, G. M., Brocca, A., Pastori, S., de Cal, M., Marcante, S., Granata, A., Ronco, C. (2016) The role of cell-free plasma DNA in critically ill patients with sepsis. Blood Purif. 41, 34-40. <https://doi.org/10.1159/000440975>
4. Click, B., Ramos Rivers, C., Koutroubakis, I. E., Babichenko, D., Anderson, A. M., Hashash, J. G., Dunn, M. A., Schwartz, M., Swoger, J., Baidoo, L., Barrie, A. 3rd, Regueiro, M., Binion, D. G. (2016) Demographic and clinical predictors of high healthcare use in patients with inflammatory bowel disease. Inflamm. Bowel Dis. 22, 1442-1449. <https://doi.org/10.1097/MIB.0000000000000763>
5. Dunaeva, M., Buddingh’, B. C., Toes, R. E. M., Luime, J .J., Lubberts, E., Pruijn, G. J. M. (2015) Decreased serum cellfree DNA levels in rheumatoid arthritis. Auto Immun. Highlights 6, 23-30. <https://doi.org/10.1007/s13317-015-0066-6>
6. Koike, Y., Uchida, K., Tanaka, K., Ide, S., Otake, K., Okita, Y., Inoue, M., Araki, T., Mizoguchi, A., Kusunoki, M. (2014) Dynamic pathology for circulating free DNA in a dextran sodium sulfate colitis mouse model. Pediatr. Surg. Int. 30, 1199-1206. <https://doi.org/10.1007/s00383-014-3607-6>
7. Krieg, A. M. (2002) CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760. <https://doi.org/10.1146/annurev.immunol.20.100301.064842>
8. Laukova, L., Konecna, B., Babickova, J., Wagnerova, A., Meliskova, V., Vlkova, B., Celec, P. (2017) Exogenous deoxyribonuclease has a protective effect in a mouse model of sepsis. Biomed. Pharmacother. 93, 8-16. <https://doi.org/10.1016/j.biopha.2017.06.009>
9. Lui, Y. Y., Woo, K. S., Wang, A. Y., Yeung, C. K., Li, P. K., Chau, E., Ruygrok, P., Lo, Y. M. (2003) Origin of plasma cell-free DNA after solid organ transplantation. Clin. Chem. 49, 495-496. <https://doi.org/10.1373/49.3.495>
10. Malickova, K., Duricova, D., Bortlik, M., Hruskova, Z., Svobodova, B., Machkova, N., Komarek, V., Fucikova, T., Janatkova, I., Zima, T., Lukas, M. (2011) Impaired deoxyribonuclease I activity in patients with inflammatory bowel diseases. Autoimmune Dis. 2011, 945861.
11. Molodecky, N. A., Soon, I. S., Rabi, D. M., Ghali, W. A., Ferris, M., Chernoff, G., Benchimol, E. I., Panaccione, R., Ghosh, S., Barkema, H. W., Kaplan, G. G. (2012) Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 142, 46-54. <https://doi.org/10.1053/j.gastro.2011.10.001>
12. Muzes, G., Kiss, A. L., Tulassay, Z., Sipos, F. (2017) Cell-free DNA-induced alteration of autophagy response and TLR9- signaling: Their relation to amelioration of DSS-colitis. Comp. Immunol. Microbiol. Infect. Dis. 52, 48-57. <https://doi.org/10.1016/j.cimid.2017.06.005>
13. Nadano, D., Yasuda, T., Kishi, K. (1993) Measurement of deoxyribonuclease I activity in human tissues and body fluids by a single radial enzyme-diffusion method. Clin. Chem. 39, 448-452. <https://doi.org/10.1093/clinchem/39.3.448>
14. Nguyen, D. N., Stensballe, A., Lai, J. C., Jiang, P., Brunse, A., Li, Y., Sun, J., Mallard, C., Skeath, T., Embleton, N. D., Berrington, J. E., Sangild, P. T. (2017) Elevated levels of circulating cell-free DNA and neutrophil proteins are associated with neonatal sepsis and necrotizing enterocolitis in immature mice, pigs and infants. Innate Immun. 23, 524-536. <https://doi.org/10.1177/1753425917719995>
15. O’Driscoll, L. (2007) Extracellular nucleic acids and their potential as diagnostic, prognostic and predictive biomarkers. Anticancer Res. 27, 1257-1265.
16. Sharma, S., Fitzgerald, K. (2011) Innate immune sensing of DNA. PLoS Pathog. 7, e1001310. <https://doi.org/10.1371/journal.ppat.1001310>
17. Schneck, E., Samara, O., Koch, C., Hecker, A., Padberg, W., Lichtenstern, C., Weigand, M. A., Uhle, F. (2017) Plasma DNA and RNA differentially impact coagulation during abdominal sepsis - an explorative study. J. Surg. Res. 210, 231-243. <https://doi.org/10.1016/j.jss.2016.11.044>
18. Wirtz, S., Neufert, C., Weigmann, B., Neurath, M. F. (2007) Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2, 541-546. <https://doi.org/10.1038/nprot.2007.41>
19. Zhong, X. Y., Burk, M. R., Troeger, C., Kang, A., Holzgreve, W., Hahn, S. (2000) Fluctuation of maternal and fetal free extracellular circulatory DNA in maternal plasma. Obstet. Gynecol. 96, 991-996.
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