Fol. Biol. 2020, 66, 179-185

https://doi.org/10.14712/fb2020066050179

Caenorhabditis elegans Perilipin Is Implicated in Cold-Induced Lipolysis and Inhibits Autophagy in Early Embryos

Filip Kaššák, A. A. Chughtai, S. Kaššák, M. Kostrouchová

Biocev, First Faculty of Medicine, Charles University, Vestec, Czech Republic

Received November 2020
Accepted December 2020

References

1. Chen Y., Scarcelli, V., Legouis, R. (2017) Approaches for studying autophagy in Caenorhabditis elegans. Cells 6, 27. <https://doi.org/10.3390/cells6030027>
2. Chughtai, A. A., Kaššak, F., Kostrouchová, M., Novotný, J. P., Krause, M. W., Saudek, V., Kostrouch, Z., Kostrouchová, M. (2015) Perilipin-related protein regulates lipid metabolism in C. elegans. PeerJ 2015, e1213. <https://doi.org/10.7717/peerj.1213>
3. Cingolani, F., Czaja, M. J. (2016) Regulation and functions of autophagic lipolysis. Trends Endocrinol. Metab. 27, 696-705. <https://doi.org/10.1016/j.tem.2016.06.003>
4. Djeddi, A., Rawi, S., Deuve, J. L., Perrois, C., Liu, Y.-Y., Russeau, M., Sachse, M., Galy, V. (2015) Sperm-inherited organelle clearance in C. elegans relies on LC3-dependent autophagosome targeting to the pericentrosomal area. Development 142, 1705-1716. <https://doi.org/10.1242/dev.117879>
5. Liu, F., Xiao, Y., Ji, X.-L., Zhang, K.-Q., Zou, C.-G. (2017) The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans. Sci. Rep. 7, 638. <https://doi.org/10.1038/s41598-017-00630-w>
6. Manil-Ségalen, M., Lefebvre, C., Jenzer, C., Trichet, M., Boulogne, C., Satiat-Jeunemaitre, B., Legouis, R. (2014) The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39. Dev. Cell 28, 43-55. <https://doi.org/10.1016/j.devcel.2013.11.022>
7. Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., Levine, B. (2003) Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301, 1387-1391. <https://doi.org/10.1126/science.1087782>
8. Na, H., Zhang, P., Chen, Y., Zhu, X., Liu, Y., Liu, Y., Xie, K., Xu, N., Yang, F., Yu, Y., Cichello,S., Mak, H. Y., Wang, M. C., Zhang, H., Liu P. (2015) Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans. Biochim. Biophys. Acta 1853, 2481-2491. <https://doi.org/10.1016/j.bbamcr.2015.05.020>
9. O’Rourke, E. J., Soukas, A. A., Carr, C. E., Ruvkun, G. (2009) C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab. 10, 430-435. <https://doi.org/10.1016/j.cmet.2009.10.002>
10. R Core Team (2014) R: A language and environment for statistical computing.
11. Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., Tinevez, J. Y., White, D. J., Hartenstein, V., Eliceiri, K., Tomancak, P., Cardona, A. (2012) Fiji: an open-source platform for biological-image analysis. Nat. Methods 9, 676-682. <https://doi.org/10.1038/nmeth.2019>
12. Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., Czaja, M. J. (2009) Autophagy regulates lipid metabolism. Nature 458, 1131-1135. <https://doi.org/10.1038/nature07976>
13. Stiernagle, T. (2006) Maintenance of C. elegans. WormBook 1-11.
14. Subramanian, V., Rothenberg, A., Gomez, C., Cohen, A. W., Garcia, A., Bhattacharyya, S., Shapiro, L., Dolios, G., Wang, R., Lisanti, M. P., Brasaemle, D. L. (2004) Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J. Biol. Chem. 279, 42062-42071. <https://doi.org/10.1074/jbc.M407462200>
15. Sztalryd, C., Xu, G., Dorward, H., Tansey, J. T., Contreras, J. A., Kimmel, A. R., Londos, C. (2003) Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J. Cell Biol. 161, 1093-1103. <https://doi.org/10.1083/jcb.200210169>
16. Sztalryd, C., Brasaemle, D. L. (2017) The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1862, 1221-1232. <https://doi.org/10.1016/j.bbalip.2017.07.009>
17. Vrablik, T. L., Petyuk, V. A., Larson, E. M., Smith, R. D., Watts, J. L. (2015) Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein. Biochim. Biophys. Acta 1851, 1337-1345. <https://doi.org/10.1016/j.bbalip.2015.06.004>
18. Zhang, H., Chang, J. T., Guo, B., Hansen, M., Jia, K., Kovács, A. L., Kumsta, C., Lapierre, L. R., Legouis, R., Lin, L., Lu, Q., Meléndez, A., O’Rourke, E. J., Sato, K., Sato, M., Wang, X., Wu, F. (2015) Guidelines for monitoring autophagy in Caenorhabditis elegans. Autophagy 11, 9-27.
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