Fol. Biol. 2021, 67, 49-61
https://doi.org/10.14712/fb2021067020049
Acylated Ghrelin Administration Inhibits Sleeve Gastrectomy - Induced Hippocampal Oxidative Stress, Apoptosis and Tau-Hyperphosphorylation by Activating the PI3K/Akt Pathway
References
1. 2006) Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116, 3229-3239.
< , A., Liu, Z. W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., Gao, X. B., Horvath, T. L. (https://doi.org/10.1172/JCI29867>
2. 2016) Neurological complications of bariatric surgery. Neurosciences 21, 241-245.
< , H. A., Khan, A. S., Khan, M. A., Aldarmahi, A. A., Lodhi, Y. (https://doi.org/10.17712/nsj.2016.3.20160039>
3. 2001) Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J. Clin. Endocrinol. Metab. 86, 4753-4758.
< , H., Takaya, K., Tagami, T., Ogawa, Y., Hosoda, K., Akamizu, T., Suda, M., Koh, T., Natsui, K., Toyooka, S., Shirakami, G., Usui, T., Shimatsu, A., Doi, K., Hosoda, H., Kojima, M., Kangawa, K., Nakao, K. (https://doi.org/10.1210/jcem.86.10.7885>
4. 2015) Evaluation of passive avoidance learning and spatial memory in rats exposed to low levels of lead during specific periods of early brain development. Int. J. Occup. Environ. Health 28, 533-544.
< , R. R., Bairy, L. K. (https://doi.org/10.13075/ijomeh.1896.00283>
5. 2013) Serum ghrelin is associated with verbal learning and adiposity in a sample of healthy, fit older adults. BioMed Res. Int. 202757.
, D., Glickman, E. L., Judge, L. W., Gunstad, J. (
6. 2012) Ghrelin promotes reorganization of dendritic spines in cultured rat hippocampal slices. Neurosci. Lett. 516, 280-284.
< , L., Isokawa, M. (https://doi.org/10.1016/j.neulet.2012.04.009>
7. 2006) Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study ‘recognition memory’. Nat. Protoc. 1, 1306-1311.
< , R. A., Besheer, J. (https://doi.org/10.1038/nprot.2006.205>
8. 2014) Dietary intake and ghrelin and leptin changes after sleeve gastrectomy. Videosurg. Other Miniinvasive Tech. 9, 554-561.
< , M., Zavadilová, V., Holéczy, P., Švagera, Z., Švorc, P., Foltys, A., Zonča, P. (https://doi.org/10.5114/wiitm.2014.45437>
9. 2017) The relation between laparoscopic sleeve gastrectomy and ghrelin. International Journal of Medical Research and Health Sciences 6, 29-35.
, S. Köksal E. (
10. 2008) Decreased memory for novel object recognition in chronically food-restricted mice is reversed by acute ghrelin administration. Neuroscience 153, 929-934.
< , V. P., Martini, A. C., Schiöth, H. B., Ruiz, R. D., Fiol de Cuneo, M., de Barioglio, S. R. (https://doi.org/10.1016/j.neuroscience.2008.03.015>
11. 2010) Ghrelin and memory: differential effects on acquisition and retrieval. Peptides 31, 1190-1193.
< , V. P., Ghersi, M., Schiöth, H. B., de Barioglio, S. R. (https://doi.org/10.1016/j.peptides.2010.02.021>
12. 2007) Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 148, 148-159.
< , H., Kim, E., Lee, D. H., Seo, S., Ju, S., Lee, D., Kim, H., Park, S. (https://doi.org/10.1210/en.2006-0991>
13. 2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37, 649-661.
< , M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., Garcia-Segura, L. M., Nillni, E. A., Mendez, P., Low, M. J., Sotonyi, P., Friedman, J. M., Liu, H., Pinto, S., Colmers, W. F., Cone, R. D., Horvath, T. L. (https://doi.org/10.1016/S0896-6273(03)00063-1>
14. 2006) Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9, 381-388.
< , S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., Morley, J. E., Pinto, S., Sherwin, R. S., Xu, L., Yamada, K. A., Sleeman, M. W., Tschöp, M. H., Horvath, T. L. (https://doi.org/10.1038/nn1656>
15. 2010) Expression of the ghrelin and neurotensin systems is altered in the temporal lobe of Alzheimer’s disease patients. J. Alzheimer’s Dis. 22, 819-828.
< , M. D., Rubio, A., Córdoba-Chacón, J., Gracia-Navarro, F., Kineman, R. D., Avila, J., Luque, R. M., Castaño, J. P. (https://doi.org/10.3233/JAD-2010-100873>
16. 2013) Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight. J. Endocrinol. 220, R1-R24.
< , M. D., Rincón-Fernández, D., Villa-Osaba, A., Hormaechea-Agulla, D., Ibáñez-Costa, A., Martínez-Fuentes, A. J., Gracia-Navarro, F., Castaño, J. P., Luque, R. M. (https://doi.org/10.1530/JOE-13-0391>
17. 2007) Systemic and brain metabolic dysfunction as a new paradigm for approaching Alzheimer’s dementia. Neurochem. Res. 32, 555–567.
< , V., Peluso, G., Iannuccelli, M., Benatti, P., Nicolai, R., Calvani, M. (https://doi.org/10.1007/s11064-006-9125-8>
18. 2014) Protective effect of leptin and ghrelin against toxicity induced by amyloid-β oligomers in a hypothalamic cell line. J. Neuroendocrinol. 26, 176-185.
< , S., Martins, I., Fonseca, A. C., Oliveira, C. R., Resende, R., Pereira, C. M. (https://doi.org/10.1111/jne.12138>
19. 2017) Cholinergic modulation of the hippocampal region and memory function. J. Neurochem. 142, 111-121.
< , J., Yakel, J. L. (https://doi.org/10.1111/jnc.14052>
20. 2014) Influence of ghrelin on the central serotonergic signaling system in mice. NEPHBW 79, 498-505.
, C., Alvarez-Crespo, M., Taube, M., Skibicka, K. P., Schmidt, L., Karlsson-Lindahl, L., Egecioglu, E., Nissbrandt, H., Dickson, S. L. (
21. 2017) From belly to brain: targeting the ghrelin receptor in appetite and food intake regulation. Int. J. Mol. Sci. 18, 273.
< , K., Griffin, B. T., Cryan, J. F., Schellekens, H. (https://doi.org/10.3390/ijms18020273>
22. 2014) Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles. Biochem. Pharmacol. 88, 631-639.
< , K., Liu, F., Gong, C. X. (https://doi.org/10.1016/j.bcp.2014.01.002>
23. 2018) MK-0677, a ghrelin agonist, alleviates amyloid beta-related pathology in 5XFAD mice, an animal model of Alzheimer’s disease. Int. J. Mol. Sci. 19, 1800.
< , Y. O., Shin, S. J., Park, J. Y., Ku, B. K., Song, J. S., Kim, J. J., Jeon, S. G., Lee, S. M., Moon, M. (https://doi.org/10.3390/ijms19061800>
24. 2015) Central acylated ghrelin improves memory function and hippocampal AMPK activation and partly reverses the impairment of energy and glucose metabolism in rats infused with β-amyloid. Peptides 71, 84-93.
< , S., Moon, N. R., Kim, D. S., Kim, S. H., Park, S. (https://doi.org/10.1016/j.peptides.2015.07.005>
25. 1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656-660.
< , M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., Kangawa, K. (https://doi.org/10.1038/45230>
26. 2015) Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer’s disease mouse model. Sci. Rep. 5, 11452.
< , N., van Groen, T., Allison, D. B., Kumar, A., Dozier- Sharpe, M., Kadish, I. (https://doi.org/10.1038/srep11452>
27. 2011) Molecular implication of PP2A and Pin1 in the Alzheimer’s disease specific hyperphosphorylation of Tau. PloS One 6, e21521.
< , I., Smet-Nocca, C., Amniai, L., Louis, J. V., Wieruszeski, J. M., Goris, J., Janssens, V., Lippens, G. (https://doi.org/10.1371/journal.pone.0021521>
28. 2013) Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory. Endocr. J. 60, 781-789.
< , E., Chung, H., Kim, Y., Kim, D. H., Ryu, J. H., Sato, T., Kojima, M., Park, S. (https://doi.org/10.1507/endocrj.EJ13-0008>
29. 2011) Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev. Cell 21, 92-101.
< , J. C., Youle, R. J. (https://doi.org/10.1016/j.devcel.2011.06.017>
30. 2014) Impaired hippocampal neurogenesis and its enhancement with ghrelin in 5XFAD mice. J. Alzheimer’s Dis. 41, 233-241.
< , M., Cha, M. Y., Mook-Jung, I. (https://doi.org/10.3233/JAD-132417>
31. 1984) Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11, 47-60.
< R. (https://doi.org/10.1016/0165-0270(84)90007-4>
32. 2020) Hemostatic effect of acylated ghrelin in control and sleeve gastrectomy-induced rats: mechanisms of action. Arch. Physiol. Biochem. 126, 31-40.
< M. D. (https://doi.org/10.1080/13813455.2018.1489849>
33. 2010) Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice. Eur. J. Neurosci. 32, 632-639.
< , Z. R., Ducharme, R., Anisman, H., Abizaid, A. (https://doi.org/10.1111/j.1460-9568.2010.07310.x>
34. 2017) Role of GSK3β and PP2A on regulation of tau phosphorylation in hippocampus and memory impairment in ICV-STZ animal model of Alzheimer’s disease. Adv. Alzheimer. Dis. 13, 31.
, T., Hong, E., Abascal-Díaz, M., Meneses, A. (
35. 2007) Tau phosphorylation by GSK-3β promotes tangle-like filament morphology. Mol. Neurodegener. 2, 12.
< , C. A., Sun, Q., Gamblin, T. C. (https://doi.org/10.1186/1750-1326-2-12>
36. 2002) Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients. J. Endocrinol. 175, 1-5.
< , A. E., Pincelli, A. I., Corrà, B., Viarengo, R., Bonomo, S. M., Galimberti, D., Scacchi, M., Scarpini, E., Cavagnini, F., Müller, E. E. (https://doi.org/10.1677/joe.0.175r001>
37. 2017) Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid β (Aβ1-40) administration in mice. J. Neuroendocrinol. 29, 1-11.
< , V. V., Stark, R., Rial, D., Silva, H. B., Bayliss, J. A., Lemus, M. B., Davies, J. S., Cunha, R. A., Prediger, R. D., Andrews, Z. B. (https://doi.org/10.1111/jne.12476>
38. 2002) Alzheimer’s disease: genes, proteins, and therapy. Physiol. Rev. 81, 741-766.
< D. J. (https://doi.org/10.1152/physrev.2001.81.2.741>
39. 2018) The neurocognitive effects of ghrelin-induced signalling on the hippocampus: a promising approach to Alzheimer’s disease. Cureus 10, e3285.
, R. S., Jeet, C., Biswas, S., Kanwal, B., Iftikhar, W., Sakibuzzaman, M., Rutkofsky, I. H. (
40. 2019) Trans-resveratrol inhibits tau phosphorylation in the brains of control and cadmium chloride-treated rats by activating PP2A and PI3K/Akt induced- inhibition of GSK3β. Neurochem. Res. 44, 357-373.
< , A. A., Alfaifi, M. Y. (https://doi.org/10.1007/s11064-018-2683-8>
41. 2017) The hippocampus and the regulation of human food intake. Psychol. Bull. 143, 1011-1032.
< , R. J., Francis, H. M. (https://doi.org/10.1037/bul0000109>
42. 2014) Ghrelin: a link between ageing, metabolism and neurodegenerative disorders. Neurobiol. Dis. 72, 72-83.
< I. I. (https://doi.org/10.1016/j.nbd.2014.08.026>
43. 2014) Abeta, oxidative stress in Alzheimer disease: evidence based on proteomics studies. Biochim. Biophys. Acta 1842, 1248-1257.
< , A. M., Förster, S., Keeney, J. T., Triplett, J., Zhang, Z., Sultana, R., Butterfield, D. A. (https://doi.org/10.1016/j.bbadis.2013.09.015>
44. 2009) Intraamygdaloid microinjection of acylated-ghrelin influences passive avoidance learning. Behav. Brain Res. 202, 308-311.
< , K., László, K., Lukács, E., Lénárd, L. (https://doi.org/10.1016/j.bbr.2009.03.031>
45. 2011) Sleeve gastrectomy induces weight loss in diet-induced obese rats even if high-fat feeding is continued. Obes. Surg. 21, 14381443.
< , V., Martín, M., Ramírez, B., Gómez-Ambrosi, J., Rodríguez, A., Catalán, V. , Sara Becerril, S., Lancha, A., Fernández, S., Cienfuegos, J., Burrell, M., Frühbeck, G. (https://doi.org/10.1007/s11695-010-0277-x>
46. 2018) Current understanding of Alzheimer’s disease diagnosis and treatment. F1000Res. 7, 1161.
< , J., Budson, A. (https://doi.org/10.12688/f1000research.14506.1>
47. 2004) The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur. J. Neurosci. 19, 1699-1707.
< , A., Ying, Z., Gomez-Pinilla, F. (https://doi.org/10.1111/j.1460-9568.2004.03246.x>
48. 2013) Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signalling pathways. J. Agric. Food Chem. 61, 1509-1520.
< , H., Wang, J., Yuan, L., Xiao, C., Wang, Y., Liu, X. (https://doi.org/10.1021/jf3050268>
49. 2013) The role of ghrelin in patients with functional dyspepsia and its potential clinical relevance (Review). Int. J. Mol. Med. 32, 523-531.
< , T., Asakawa, A., Ueda, H., Miyawaki, S., Inui, A. (https://doi.org/10.3892/ijmm.2013.1418>
50. 2013) Acylated ghrelin protects hippocampal neurons in pilocarpine- induced seizures of immature rats by inhibiting cell apoptosis. Mol. Biol. Rep. 40, 51-58.
< , R., Yang, G., Wang, Q., Guo, F., Wang, H. (https://doi.org/10.1007/s11033-012-1993-1>
51. 2011) Implication of phosphatidylinositol-3 kinase/Akt/glycogen synthase kinase-3β pathway in ginsenoside Rb1’s attenuation of β-amyloid-induced neurotoxicity and tau phosphorylation. J. Ethnopharmacol. 133, 1109-1116.
< , R., Zhang, Z., Song, Y., Wang, D., Qi, J., Wen, S. (https://doi.org/10.1016/j.jep.2010.11.054>