Fol. Biol. 2021, 67, 102-107
https://doi.org/10.14712/fb2021067030102
Inhibition of SRSF3 Alleviates Proliferation and Migration of Gastric Cancer Cells by Regulating the PI3K/AKT/mTOR Signalling Pathway
References
1. , Y., Fu, L. (2020) Aberrant expression and regulatory network of splicing factor-SRSF3 in tumors. J. Cancer 11, 3502-3511.
<https://doi.org/10.7150/jca.42645>
2. , C. C., Cantley, L. C. (2015) Regulation of mTORC1 by PI3K signaling. Trends Cell Biol. 25, 545-555.
<https://doi.org/10.1016/j.tcb.2015.06.002>
3. , S., Amjadi-Moheb, F., Tabaripour, R., Ashrafi, G. H., Akhavan-Niaki, H. (2020) PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond. Life Sci. 262, 118513.
<https://doi.org/10.1016/j.lfs.2020.118513>
4. 2017 Stomach Cancer Collaborators (2020) The global, regional, and national burden of stomach cancer in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease study 2017. Lancet Gastroenterol. Hepatol. 5, 42-54.
5. , J., Jia, J., Jia, R. (2015) PTBP1 and PTBP2 impaired autoregulation of SRSF3 in cancer cells. Sci Rep. 5, 14548.
<https://doi.org/10.1038/srep14548>
6. , Y. K., Kang, W. M., Ma, Z. Q., Liu, Y. Q., Zhou, L., Yu, J. C. (2019) NUCKS1 promotes gastric cancer cell aggressiveness by upregulating IGF-1R and subsequently activating the PI3K/Akt/mTOR signaling pathway. Carcinogenesis 40, 370-379.
<https://doi.org/10.1093/carcin/bgy142>
7. , R., Ajiro, M., Yu, L., McCoy, P., Jr., Zheng, Z. M. (2019) Oncogenic splicing factor SRSF3 regulates ILF3 alternative splicing to promote cancer cell proliferation and transformation. RNA 25, 630-644.
<https://doi.org/10.1261/rna.068619.118>
8. , H. R., Hwang, S. J., Shin, C. H., Choi, K. H., Ohn, T., Kim, H. H. (2017) SRSF3-regulated miR-132/212 controls cell migration and invasion by targeting YAP1. Exp. Cell Res. 358, 161-170.
<https://doi.org/10.1016/j.yexcr.2017.06.009>
9. , M., Sabatini, D. M. (2009) mTOR signaling at a glance. J. Cell Sci. 122, 3589-3594.
<https://doi.org/10.1242/jcs.051011>
10. , B., Liu, W., Chen, P., Cui, R., Li, Y., Ji, M., Hou, P., Yang, Q. (2020) NVP-BEZ235 inhibits thyroid cancer growth by p53-dependent/independent p21 upregulation. Int. J. Biol. Sci. 16, 682-693.
<https://doi.org/10.7150/ijbs.37592>
11. , R. E., Al Hallak, M. N., Diab, M., Azmi, A. S. (2020) Gastric cancer: a comprehensive review of current and future treatment strategies. Cancer Metastasis Rev. 39, 1179-1203.
<https://doi.org/10.1007/s10555-020-09925-3>
12. , T., Li, H., Song, Y., Li, L., Lin, J., Wei, G., Ni, T. (2019) Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence. Aging (Albany NY) 11, 1356-1388.
<https://doi.org/10.18632/aging.101836>
13. , P. J., Hertel, K. J. (2009) The SR protein family. Genome Biol. 10, 242.
<https://doi.org/10.1186/gb-2009-10-10-242>
14. , X., Wan, X., Huang, T., Zeng, C., Sastry, N., Wu, B., James, C. D., Horbinski, C., Nakano, I., Zhang, W., Hu, B., Cheng, S. Y. (2019) SRSF3-regulated RNA alternative splicing promotes glioblastoma tumorigenicity by affecting multiple cellular processes. Cancer Res. 79, 5288-5301.
<https://doi.org/10.1158/0008-5472.CAN-19-1504>
15. , J. L., Guo, C. R., Sun, T. T., Su, W. Y., Hu, Q., Guo, F. F., Liang, L. X., Xu, J., Xiong, H., Fang, J. Y. (2020) SRSF3 functions as an oncogene in colorectal cancer by regulating the expression of ArhGAP30. Cancer Cell Int. 20, 120.
<https://doi.org/10.1186/s12935-020-01201-2>
16. , S., Yan, L., Zhao, Z., Rong, F. (2019) Up-regulation of miR-203 inhibits the growth of cervical cancer cells by inducing cell cycle arrest and apoptosis Eur. J. Gynaecol. Oncol. 40, 791-795.
17. , Z., Gong, Q., Lin, Z., Wang, Y., Li, M., Wang, L., Ding, H., Li, P. (2020) Emerging roles of SRSF3 as a therapeutic target for cancer. Front. Oncol. 10, 577636.
<https://doi.org/10.3389/fonc.2020.577636>
