Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

Crossref logo

Fol. Biol. 2022, 68, 59-71

https://doi.org/10.14712/fb2022068020059

Docosahexaenoic Acid Reverses Epithelial-Mesenchymal Transition and Drug Resistance by Impairing the PI3K/AKT/Nrf2/GPX4 Signalling Pathway in Docetaxel-Resistant PC3 Prostate Cancer Cells

Z. C. Shao1,2, B. H. Zhu2, A. F. Huang2, M. Q. Su1,2, L. J. An1,2, Z. P. Wu2,3, Y. J. Jiang2, H. Guo2, X.-Q. Han2, Chi-Ming Liu2

1College of Chemistry and Bio-engineering, Yichun University, Yuanzhou District, Yichun 336000, Jiangxi Province, China
2School of Medicine, Yichun University, Yuanzhou District, Yichun 336000, Jiangxi Province, China
3School of Aesthetic Medicine, Yuanzhou District, Yichun 336000, Jiangxi Province, China

Received November 2021
Accepted April 2022

Crossref Cited-by Linking

  • . <https://doi.org/10.46879/ukroj.4.2024.459-477>
  • Yan Dong, Hou Yingshan, Lei Xinyi, Xiao Hao, Zeng Zhaoyang, Xiong Wei, Fan Chunmei: The Impact of Polyunsaturated Fatty Acids in Cancer and Therapeutic Strategies. Curr Nutr Rep 2025, 14. <https://doi.org/10.1007/s13668-025-00639-y>
  • Yang Hubo, Zhang Xuefeng, Jia Zongming, Wang He, Wu Jixiang, Wei Xuedong, Huang Yuhua, Yan Wenying, Lin Yuxin: Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives. J Transl Med 2025, 23. <https://doi.org/10.1186/s12967-025-06180-4>
  • Xiang Lei, Li Qingzhou, Guan Zhiwei, Wang Guilin, Yu Xiankuo, Zhang Xianwen, Zhang Guochen, Hu Jushan, Yang Xue, Li Mingrui, Bao Xilinqiqige, Wang Yumei, Wang Dong: Oxyresveratrol as a novel ferroptosis inducer exhibits anticancer activity against breast cancer via the EGFR/PI3K/AKT/GPX4 signalling axis. Front. Pharmacol. 2025, 15. <https://doi.org/10.3389/fphar.2024.1527286>
  • Modica Roberta, La Salvia Anna, Liccardi Alessia, Cozzolino Alessia, Di Sarno Antonella, Russo Flaminia, Colao Annamaria, Faggiano Antongiulio: Dyslipidemia, lipid-lowering agents and neuroendocrine neoplasms: new horizons. Endocrine 2024, 85, 520. <https://doi.org/10.1007/s12020-024-03767-7>
  • Liu Lin, Ye Guanlong, Huang Wei, He Yang, Xie Donghao: Shen-Qi-Ling-Bi Decoction Inhibits Colorectal Cancer Cell Growth by Inducing Ferroptosis Through Inactivation of PI3K/AKT Signaling Pathway. DNA and Cell Biology 2024, 43, 315. <https://doi.org/10.1089/dna.2023.0434>
  • Su Hua, Peng Chao, Liu Yang: Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer. Front. Cell Dev. Biol. 2024, 12. <https://doi.org/10.3389/fcell.2024.1372330>
  • Cassano Roberta, Trombino Sonia, Curcio Federica, Sole Roberta, Calviello Gabriella, Serini Simona: ROS-Responsive PLGA-NPs for Co-Delivery of DTX and DHA for Colon Cancer Treatment. IJTM 2024, 4, 262. <https://doi.org/10.3390/ijtm4020016>
  • Lee Jaewang, Roh Jong-Lyel: Epithelial-mesenchymal plasticity: Implications for ferroptosis vulnerability and cancer therapy. Critical Reviews in Oncology/Hematology 2023, 185, 103964. <https://doi.org/10.1016/j.critrevonc.2023.103964>
  • He Peng, Dai Qiang, Wu Xiaojun: New insight in urological cancer therapy: From epithelial-mesenchymal transition (EMT) to application of nano-biomaterials. Environmental Research 2023, 229, 115672. <https://doi.org/10.1016/j.envres.2023.115672>
  • Liang Jiaming, Liao Yihao, Wang Pu, Yang Kun, Wang Youzhi, Wang Keke, Zhong Boqiang, Zhou Diansheng, Cao Qian, Li Junbo, Zhao Yang, Jiang Ning: Ferroptosis landscape in prostate cancer from molecular and metabolic perspective. Cell Death Discov. 2023, 9. <https://doi.org/10.1038/s41420-023-01430-0>
  • Wen Hongzhuang, Qu Changbao, Wang Zhu, Gao Haitao, Liu Wuyao, Wang Hu, Sun Hao, Gu Junfei, Yang Zhan, Wang Xiaolu: Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer. The FASEB Journal 2023, 37. <https://doi.org/10.1096/fj.202300980R>
  • Vít Ondřej, Petrák Jiří: Autotaxin and Lysophosphatidic Acid Signalling: the Pleiotropic Regulatory Network in Cancer. Fol. Biol. 2023, 69, 149. <https://doi.org/10.14712/fb2023069050149>
  • Montecillo-Aguado Mayra, Tirado-Rodriguez Belen, Huerta-Yepez Sara: The Involvement of Polyunsaturated Fatty Acids in Apoptosis Mechanisms and Their Implications in Cancer. IJMS 2023, 24, 11691. <https://doi.org/10.3390/ijms241411691>
  • de Freitas Rodrigues Jaqueline, Philippsen Hellen Kempfer, Dolabela Maria Fani, Nagamachi Cleusa Yoshiko, Pieczarka Julio Cesar: The Potential of DHA as Cancer Therapy Strategies: A Narrative Review of In Vitro Cytotoxicity Trials. Nutrients 2023, 15, 2006. <https://doi.org/10.3390/nu15082006>
Crossref Cited-by Linking logo