Fol. Biol. 2024, 70, 53-61

https://doi.org/10.14712/fb2024070010053

Gallic Acid Alleviates Psoriasis Keratinization and Inflammation by Regulating BRD4 Expression

Li Zhang1, Qiaoyuan Ye2, Saiyang Gan1, Huan Liu1, Qing Zhang1, Shuangshuang Wang1, Can Cheng3

1Dermatology Department, ShenZhen Qianhai Shekou Free Trade Zone Hospital, China
2Department of Dermatology and Venereology, Second Clinical Medical College of Guangdong Medical University, China
3Shenzhen Polytechnic, China

Received November 2023
Accepted January 2024

References

1. Al Zahrani, N. A., El-Shishtawy, R. M., Asiri, A. M. (2020) Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: a review. Eur. J. Med. Chem. 204, 112609. <https://doi.org/10.1016/j.ejmech.2020.112609>
2. Albanesi, C., Madonna, S., Gisondi, P. et al. (2018) The interplay between keratinocytes and immune cells in the pathogenesis of psoriasis. Front Immunol. 9, 1549. <https://doi.org/10.3389/fimmu.2018.01549>
3. Altendorfer, E., Mochalova, Y., Mayer, A. (2022) BRD4: a general regulator of transcription elongation. Transcription 13, 70-81. <https://doi.org/10.1080/21541264.2022.2108302>
4. Armstrong, A. W., Read, C. (2020) Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA 323, 1945-1960. <https://doi.org/10.1001/jama.2020.4006>
5. Bai, J., Zhang, Y., Tang, C. et al. (2021) Gallic acid: pharmacological activities and molecular mechanisms involved in inflammation-related diseases. Biomed. Pharmacother. 133, 110985. <https://doi.org/10.1016/j.biopha.2020.110985>
6. Bakshi, H., Nagpal, M., Singh, M. et al. (2020) Treatment of psoriasis: a comprehensive review of entire therapies. Curr. Drug Saf. 15, 82-104. <https://doi.org/10.2174/1574886315666200128095958>
7. Benhadou, F., Mintoff, D., Del Marmol, V. (2019) Psoriasis: keratinocytes or immune cells – which is the trigger? Dermatology 235, 91-100. <https://doi.org/10.1159/000495291>
8. Brandon, A., Mufti, A., Sibbald, R. G. (2019) Diagnosis and management of cutaneous psoriasis: a review. Adv. Skin Wound Care 32, 58-69. <https://doi.org/10.1097/01.ASW.0000550592.08674.43>
9. da Silva, A. P. G. (2021) Fighting coronaviruses with natural polyphenols. Biocatal. Agric. Biotechnol. 37, 102179. <https://doi.org/10.1016/j.bcab.2021.102179>
10. Dainichi, T., Kitoh, A., Otsuka, A. et al. (2018) The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis. Nat. Immunol. 19, 1286-1298. <https://doi.org/10.1038/s41590-018-0256-2>
11. de Melo, K. D. C. M., dos Santos Lisboa, L., Queiroz, M. F. et al. (2022) Antioxidant activity of fucoidan modified with gallic acid using the redox method. Mar. Drugs 20, 490. <https://doi.org/10.3390/md20080490>
12. Donati, B., Lorenzini, E., Ciarrocchi, A. et al. (2018) BRD4 and cancer: going beyond transcriptional regulation. Mol. Cancer 17, 164. <https://doi.org/10.1186/s12943-018-0915-9>
13. Fan, Y., Piao, C. H., Hyeon, E. et al. (2019) Gallic acid alleviates nasal inflammation via activation of Th1 and inhibition of Th2 and Th17 in a mouse model of allergic rhinitis. Int. Immunopharmacol. 70, 512-519. <https://doi.org/10.1016/j.intimp.2019.02.025>
14. Fujita, H., Gooderham, M., Romiti, R. (2022) Diagnosis of generalized pustular psoriasis. Am. J. Clin. Dermatol. 23, 31-38. <https://doi.org/10.1007/s40257-021-00652-1>
15. Furue, K., Ito, T., Tsuji, G. et al. (2019) Psoriasis and the TNF/IL23/IL17 axis. G. Ital. Dermatol. Venereol. 154, 418-424.
16. Furue, M., Furue, K., Tsuji, G. et al. (2020) Interleukin-17A and keratinocytes in psoriasis. Int. J. Mol. Sci. 21, 1275. <https://doi.org/10.3390/ijms21041275>
17. Gao, R. L., Zeng, C. W., Li, Y. Q. (2021) Research advances in the mechanisms of BRD4 and its inhibitors in hematologic malignancies – Review. Zhongguo Shi Yan Xue Ye Xue Za Zhi 29, 1365-1368.
18. Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E. et al. (2021) Psoriasis. Lancet 397, 1301-1315. <https://doi.org/10.1016/S0140-6736(20)32549-6>
19. He, Z., Ma, Y., Chen, X. et al. (2022) Protective effects of intestinal gallic acid in neonatal dairy calves against extended-spectrum beta-lactamase producing enteroaggregative Escherichia coli infection: modulating intestinal homeostasis and colitis. Front. Nutr. 9, 864080. <https://doi.org/10.3389/fnut.2022.864080>
20. Hu, P., Wang, M., Gao, H. et al. (2021) The role of helper T cells in psoriasis. Front. Immunol. 12, 788940. <https://doi.org/10.3389/fimmu.2021.788940>
21. Jiang, Y., Pei, J., Zheng, Y. et al. (2022) Gallic acid: a potential anti-cancer agent. Chin. J. Integr. Med. 28, 661-671. <https://doi.org/10.1007/s11655-021-3345-2>
22. Jin, X., Yan, Y., Wang, D. et al. (2018) DUB3 promotes BET inhibitor resistance and cancer progression by deubiquitinating BRD4. Mol. Cell 71, 592-605.e4. <https://doi.org/10.1016/j.molcel.2018.06.036>
23. Kaeley, G. S., Eder, L., Aydin, S. Z. et al. (2021) Nail psoriasis: diagnosis, assessment, treatment options, and unmet clinical needs. J. Rheumatol. 48, 1208-1220. <https://doi.org/10.3899/jrheum.201471>
24. Kamiya, K., Kishimoto, M., Sugai, J. et al. (2019) Risk factors for the development of psoriasis. Int. J. Mol. Sci. 20, 4347. <https://doi.org/10.3390/ijms20184347>
25. Liang, Y., Tian, J., Wu, T. (2021) BRD4 in physiology and pathology: “BET” on its partners. Bioessays 43, e2100180. <https://doi.org/10.1002/bies.202100180>
26. Lu, J., Wang, Y., Wang, J. et al. (2023) Circ_0082476 targets miR-138-5p to promote proliferation, invasion, migration and inflammation in IL-22-treated human keratinocytes by upregulating BRD4. Int. Immunopharmacol. 119, 110095. <https://doi.org/10.1016/j.intimp.2023.110095>
27. Ni, X., Lai, Y. (2020) Keratinocyte: a trigger or an executor of psoriasis? J. Leukoc. Biol. 108, 485-491. <https://doi.org/10.1002/JLB.5MR0120-439R>
28. Orsmond, A., Bereza-Malcolm, L., Lynch, T. (2021) Skin barrier dysregulation in psoriasis. Int. J. Mol. Sci. 22, 10841. <https://doi.org/10.3390/ijms221910841>
29. Pan, M., Huang, Y., Zhu, X. et al. (2019) MiR‑125b‑mediated regulation of cell proliferation through the Jagged‑1/Notch signaling pathway by inhibiting BRD4 expression in psoriasis. Mol. Med. Rep. 19, 5227-5236.
30. Pereira, M. M., de Morais, H., Dos Santos Silva, E. et al. (2018) The antioxidant gallic acid induces anxiolytic-, but not antidepressant-like effect, in streptozotocin-induced diabetes. Metab. Brain Dis. 33, 1573-1584. <https://doi.org/10.1007/s11011-018-0264-9>
31. Petit, R. G., Cano, A., Ortiz, A. et al. (2021) Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics. Int. J. Mol. Sci. 22, 4983. <https://doi.org/10.3390/ijms22094983>
32. Rendon, A., Schäkel, K. (2019) Psoriasis pathogenesis and treatment. Int. J. Mol. Sci. 20, 1475. <https://doi.org/10.3390/ijms20061475>
33. Rioux, G., Ridha, Z., Simard, M. et al. (2020) Transcriptome profiling analyses in psoriasis: a dynamic contribution of keratinocytes to the pathogenesis. Genes (Basel) 11, 1155. <https://doi.org/10.3390/genes11101155>
34. Sheikh, A., Hazari, S. A., Molugulu, N. et al. (2023) Hyaluronic acid engineered gallic acid embedded chitosan nanoparticle as an effective delivery system for treatment of psoriasis. Environ. Res. 238 (Pt 1), 117086. <https://doi.org/10.1016/j.envres.2023.117086>
35. Shou, S., Yang, L., Yang, Y. et al. (2021) Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation. Cell Death Dis. 12, 1009. <https://doi.org/10.1038/s41419-021-04284-5>
36. Sohrabi, F., Dianat, M., Badavi, M. et al. (2020) Does gallic acid improve cardiac function by attenuation of oxidative stress and inflammation in an elastase-induced lung injury? Iran J. Basic Med. Sci. 23, 1130-1138.
37. Sun, X., Yang, P. (2021) Inhibition of BRD4 inhibits proliferation and promotes apoptosis of psoriatic keratinocytes. Biomed. Eng. Online 20, 107. <https://doi.org/10.1186/s12938-021-00943-y>
38. Tokuyama, M., Mabuchi, T. (2020) New treatment addressing the pathogenesis of psoriasis. Int. J. Mol. Sci. 21, 7488. <https://doi.org/10.3390/ijms21207488>
39. Tsiogkas, S. G., Apostolopoulou, K., Mavropoulos, A. et al. (2023) Gallic acid diminishes pro-inflammatory interfe­ron-γ- and interleukin-17-producing sub-populations in vitro in patients with psoriasis. Immunol. Res. 71, 475-487. <https://doi.org/10.1007/s12026-023-09361-9>
40. Tu, J., Yin, Z., Guo, J. et al. (2020) Acitretin inhibits IL-17A-induced IL-36 expression in keratinocytes by down-regulating IκBζ. Int. Immunopharmacol. 79, 106045. <https://doi.org/10.1016/j.intimp.2019.106045>
41. Vičić, M., Kaštelan, M., Brajac, I. et al. (2021) Current concepts of psoriasis immunopathogenesis. Int. J. Mol. Sci. 22, 11574. <https://doi.org/10.3390/ijms222111574>
42. Wang, J., Xu, Y., Rao, X. et al. (2022) BRD4-IRF1 axis regulates chemoradiotherapy-induced PD-L1 expression and immune evasion in non-small cell lung cancer. Clin. Transl. Med. 12, e718. <https://doi.org/10.1002/ctm2.718>
43. Wang, W., Tang, Y. A., Xiao, Q. et al. (2021) Stromal induction of BRD4 phosphorylation results in chromatin remodeling and BET inhibitor resistance in colorectal cancer. Nat. Commun. 12, 4441. <https://doi.org/10.1038/s41467-021-24687-4>
44. Wang, X., Zhao, H., Ma, C. et al. (2018) Gallic acid attenuates allergic airway inflammation via suppressed interleukin-33 and group 2 innate lymphoid cells in ovalbumin-induced asthma in mice. Int. Forum Allergy Rhinol. 8, 1284-1290. <https://doi.org/10.1002/alr.22207>
45. Wu, S. Y., Lee, C. F., Lai, H. T. et al. (2020) Opposing functions of BRD4 isoforms in breast cancer. Mol. Cell. 78, 1114-1132. <https://doi.org/10.1016/j.molcel.2020.04.034>
46. Xu, Y., Tang, G., Zhang, C. et al. (2021) Gallic acid and diabetes mellitus: its association with oxidative stress. Molecules 26, 7115. <https://doi.org/10.3390/molecules26237115>
47. Yan, X., Zhang, Y. L., Zhang, L. et al. (2019) Gallic acid suppresses cardiac hypertrophic remodeling and heart failure. Mol. Nutr. Food Res. 63, e1800807. <https://doi.org/10.1002/mnfr.201800807>
48. Zhang, J., Li, X., Wei, J. et al. (2018) Gallic acid inhibits the expression of keratin 16 and keratin 17 through Nrf2 in psoriasis-like skin disease. Int. Immunopharmacol. 65, 84-95. <https://doi.org/10.1016/j.intimp.2018.09.048>
49. Zhou, X., Chen, Y., Cui, C. et al. (2022) Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis. 13, 81. <https://doi.org/10.1038/s41419-022-04523-3>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive