Fol. Biol. 2024, 70, 95-103

https://doi.org/10.14712/fb2024070020095

miR-325 Supresses Cell Proliferation and Migration in Non-Small Cell Lung Cancer via Targeting DNA Ligase 1 (LIG1)

Maixia Yu, Linchan Li, Peng Xu

Shaanxi Provincial Hospital of Chinese Medicine, Lianhu District, Xi’an, Shaanxi Province, China

Received December 2022
Accepted May 2024

References

1. Agarwal, V., Bell, G. W., Nam, J.-W. et al. (2015) Predicting effective microRNA target sites in mammalian mRNAs. Elife 4, e05005. <https://doi.org/10.7554/eLife.05005>
2. Barger, J. F., Nana-Sinkam, S. P. (2015) MicroRNA as tools and therapeutics in lung cancer. Respir. Med. 109, 803-812. <https://doi.org/10.1016/j.rmed.2015.02.006>
3. Bersimbaev, R., Pulliero, A., Bulgakova, O. et al. (2020) Radon biomonitoring and microRNA in lung cancer. Int. J. Mol. Sci. 21, 2154. <https://doi.org/10.3390/ijms21062154>
4. Billeter, A. T., Barnett, R. E., Druen, D. et al. (2012) MicroRNA as a new factor in lung and esophageal cancer. Semin. Thorac. Cardiovasc. Surg. 24, 155-165. <https://doi.org/10.1053/j.semtcvs.2012.06.009>
5. Chen, X., Zhong, S., Zhu, X. et al. (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68, 3169-3177. <https://doi.org/10.1158/0008-5472.CAN-07-6636>
6. Gan, H., Lin, L., Hu, N. et al. (2019) KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR‐325‐3p. Cell Biochem. Funct. 37, 424-431. <https://doi.org/10.1002/cbf.3420>
7. Herbst, R., Heymach, J., Lippman, S. (2008) Lung cancer. N. Engl. J. Med. 359, 1367-1380. <https://doi.org/10.1056/NEJMra0802714>
8. Howes, T. R., Sallmyr, A., Brooks, R. et al. (2017) Structure-activity relationships among DNA ligase inhibitors: characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst.) 60, 29-39. <https://doi.org/10.1016/j.dnarep.2017.10.002>
9. Huang, Z., Luo, Y., Chen, C. et al. (2023) miR-325-3p reduces proliferation and promotes apoptosis of gastric cancer cells by inhibiting human antigen R. Can. J. Gastroenterol. Hepa­tol. 2023, 6882851.
10. Johnson, A., O’Donnell, M. (2005) DNA ligase: getting a grip to seal the deal. Curr. Biol. 15, R90-R92. <https://doi.org/10.1016/j.cub.2005.01.025>
11. Li, D., Li, R., Zhang, J. et al. (2015) Association between the LIG1 polymorphisms and lung cancer risk: a meta-analysis of case-control studies. Cell Biochem. Biophys. 73, 381-387. <https://doi.org/10.1007/s12013-015-0619-3>
12. Lu, G., Duan, J., Shu, S. et al. (2016) Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining. Proc. Natl. Acad. Sci. U. S. A. 113, 1256-1260. <https://doi.org/10.1073/pnas.1521597113>
13. Martínez-Terroba, E., Ezponda, T., Bértolo, C. et al. (2018) The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer. Lab. Invest. 98, 1562-1574. <https://doi.org/10.1038/s41374-018-0128-2>
14. Molina, J. R., Yang, P., Cassivi, S. D. et al. (2008) Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin. Proc. 83, 584-594. <https://doi.org/10.1016/S0025-6196(11)60735-0>
15. Morgensztern, D., Ng, S. H., Gao, F. et al. (2010) Trends in stage distribution for patients with non-small cell lung cancer: a National Cancer Database survey. J. Thorac. Oncol. 5, 29-33. <https://doi.org/10.1097/JTO.0b013e3181c5920c>
16. Osmani, L., Li, Q. K. (2017) Biomarkers in the accurate subclassification of non-small-cell lung carcinoma for targeted therapy: issues and prospects. Biomark. Med. 11, 405-407. <https://doi.org/10.2217/bmm-2017-0059>
17. Perez-Moreno, P., Brambilla, E., Thomas, R. et al. (2012) Squamous cell carcinoma of the lung: molecular subtypes and therapeutic opportunities. Clin. Cancer Res. 18, 2443-2451. <https://doi.org/10.1158/1078-0432.CCR-11-2370>
18. Ren, Y., Song, Z., Rieser, J. et al. (2023) USP15 represses hepatocellular carcinoma progression by regulation of pathways of cell proliferation and cell migration: a system biology analysis. Cancers (Basel) 15, 1371. <https://doi.org/10.3390/cancers15051371>
19. Rupaimoole, R., Slack, F. J. (2017) MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat. Rev. Drug Discov. 16, 203-222. <https://doi.org/10.1038/nrd.2016.246>
20. Schneider, C. A., Rasband, W. S., Eliceiri, K. W. (2012) NIH Image to ImageJ: 25 years of image analysis. Nat. Methods 9, 671-675. <https://doi.org/10.1038/nmeth.2089>
21. Siegel, R. L., Miller, K. D., Fuchs, H. E. et al. (2021) Cancer statistics, 2021. CA Cancer J. Clin. 71, 7-33. <https://doi.org/10.3322/caac.21654>
22. Sun, D., Urrabaz, R., Nguyen, M. et al. (2001) Elevated expression of DNA ligase I in human cancers. Clin. Cancer Res. 7, 4143-4148.
23. Sun, S., Liu, F., Xian, S. et al. (2020) miR-325-3p overexpression inhibits proliferation and metastasis of bladder cancer cells by regulating MT3. Med. Sci. Monit. 26, e920331-1.
24. Tang, Z., Li, C., Kang, B. et al. (2017) GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45, W98-W102. <https://doi.org/10.1093/nar/gkx247>
25. Tian, H., He, X., Yin, L. et al. (2015) Relationship between genetic polymorphisms of DNA ligase 1 and non-small cell lung cancer susceptibility and radiosensitivity. Genet. Mol. Res. 14, 7047-7052. <https://doi.org/10.4238/2015.June.26.14>
26. Timson, D. J., Singleton, M. R., Wigley, D. B. (2000) DNA ligases in the repair and replication of DNA. Mutat. Res. 460, 301-318. <https://doi.org/10.1016/S0921-8777(00)00033-1>
27. Torre, L. A., Bray, F., Siegel, R. L. et al. (2015) Global cancer statistics, 2012. CA Cancer J. Clin. 65, 87-108. <https://doi.org/10.3322/caac.21262>
28. Xiong, Q., Su, H. (2021) MiR-325-3p functions as a suppressor miRNA and inhibits the proliferation and metastasis of glioma through targeting FOXM1. J. Integr. Neurosci. 20, 1019-1028. <https://doi.org/10.31083/j.jin2004103>
29. Yao, S., Zhao, T., Jin, H. (2015) Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer. Biomed. Pharmacother. 70, 72-79. <https://doi.org/10.1016/j.biopha.2015.01.013>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Submissions

Archive