Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2025, 71, 79-87

https://doi.org/10.14712/fb2025071020079

Exploring the Clinical Significance and Mechanistic Role of the LINC00487/hsa-miR-663b Axis in Cell Line Models of Acute Lung Injury

Xixiang Yan1ID, Ziqi Xie2ID, Xiaoye Zheng2ID, Qing Xie2ID, Junle Yang3ID, Xiaojuan Wu2ID

1Respiratory and Critical Care Medicine, Affiliated Jianhu Hospital of Xinglin College, Nantong University, Nantong, China
2Department of Ultrasound Medicine, The Affiliated Hospital of Northwest University (Xi‘an No.3 Hospital), Xi‘an, China
3Department of Imaging Medicine, The Affiliated Hospital of Northwest University (Xi‘an No.3 Hospital), Xi‘an, China

Received March 2025
Accepted May 2025

References

1. Cui, Y., Wang, X., Lin, F. et al. (2022) MiR-29a-3p improves acute lung injury by reducing alveolar epithelial cell PANoptosis. Aging Dis. 13, 899-909. <https://doi.org/10.14336/AD.2021.1023>
2. Du, M., Shi, D., Yuan, L. et al. (2015) Circulating miR-497 and miR-663b in plasma are potential novel biomarkers for bladder cancer. Sci. Rep. 5, 10437. <https://doi.org/10.1038/srep10437>
3. Hong, J., Mo, S., Gong, F. et al. (2021) lncRNA-SNHG14 plays a role in acute lung injury induced by lipopolysaccharide through regulating autophagy via miR-223-3p/Foxo3a. Mediators Inflamm. 2021, 7890288. <https://doi.org/10.1155/2021/7890288>
4. Hong, S., Yan, Z., Wang, H. et al. (2020) miR-663b promotes colorectal cancer progression by activating Ras/Raf signaling through downregulation of TNK1. Hum. Cell 33, 104-115. <https://doi.org/10.1007/s13577-019-00294-w>
5. Hou, L., Zhang, J., Liu, Y. et al. (2021) MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2/Drp1 pathway. Free Radic. Biol. Med. 165, 219-228. <https://doi.org/10.1016/j.freeradbiomed.2021.01.045>
6. Hu, Q., Zhang, S., Yang, Y. et al. (2022) Extracellular vesicles in the pathogenesis and treatment of acute lung injury. Mil. Med. Res. 9, 61.
7. Inamo, J., Suzuki, K., Takeshita, M. et al. (2020) Identification of novel genes associated with dysregulation of B cells in patients with primary Sjogren’s syndrome. Arthritis Res. Ther. 22, 153. <https://doi.org/10.1186/s13075-020-02248-2>
8. Khemani, R. G., Smith, L., Lopez-Fernandez, Y. M. et al. (2019) Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study. Lancet Respir. Med. 7, 115-128. <https://doi.org/10.1016/S2213-2600(18)30344-8>
9. Li, Y. X., Ma, X. X., Zhao, C. L. et al. (2023a) The effect of microRNA-663b in the inhibition of interleukin-1-induced nucleus pulposus cell apoptosis and inflammatory response. J. Physiol. Pharmacol. 74. <https://doi.org/10.26402/jpp.2023.1.09>
10. Li, Z., Jin, T., Yang, R. et al. (2023b) Long non-coding RNA PFI inhibits apoptosis of alveolar epithelial cells to alleviate lung injury via miR-328-3p/Creb1 axis. Exp. Cell Res. 430, 113685. <https://doi.org/10.1016/j.yexcr.2023.113685>
11. Liu, J. Y., Jiang, Y. X., Zhang, M. Y. et al. (2021a) Comprehensive bioinformatics analysis of lipopolysaccharide-induced altered autophagy in acute lung injury and construction of underlying competing endogenous RNA regulatory mechanism. Biomed Res. Int. 2021, 6831770. <https://doi.org/10.1155/2021/6831770>
12. Liu, X., Gao, C., Wang, Y. et al. (2021b) BMSC-derived exosomes ameliorate LPS-induced acute lung injury by miR-384-5p-controlled alveolar macrophage autophagy. Oxid. Med. Cell. Longev. 2021, 9973457. <https://doi.org/10.1155/2021/9973457>
13. Long, M. E., Mallampalli, R. K., Horowitz, J. C. (2022) Pathogenesis of pneumonia and acute lung injury. Clin. Sci. (Lond.) 136, 747-769. <https://doi.org/10.1042/CS20210879>
14. Suresh, R., Kupfer, Y. Tessler, S. (2000) Acute respiratory distress syndrome. N. Engl. J. Med. 343, 660-661.
15. Wang, X., Lu, Y., Liu, Z. et al. (2022) A 9-lncRNA signature for predicting prognosis and immune response in diffuse large B-cell lymphoma. Front. Immunol. 13, 813031. <https://doi.org/10.3389/fimmu.2022.813031>
16. Wang, Y., Wang, Y., Ma, J. et al. (2023) YuPingFengSan ameliorates LPS-induced acute lung injury and gut barrier dysfunction in mice. J. Ethnopharmacol. 312, 116452. <https://doi.org/10.1016/j.jep.2023.116452>
17. Wei, S., Liu, Q. (2019) Long noncoding RNA MALAT1 modulates sepsis-induced cardiac inflammation through the miR-150-5p/NF-κB axis. Int. J. Clin. Exp. Pathol. 12, 3311-3319.
18. Yang, Q., Zhang, X., Luo, L. et al. (2023) Clinical application of serum NLRP3 on the diagnosis and prognosis of sepsis patients complicated with acute respiratory distress syndrome. Front. Immunol. 14, 1205132. <https://doi.org/10.3389/fimmu.2023.1205132>
19. Yin, X., Zheng, X., Liu, M. et al. (2020) Exosomal miR-663b targets Ets2-repressor factor to promote proliferation and the epithelial-mesenchymal transition of bladder cancer cells. Cell Biol. Int. 44, 958-965. <https://doi.org/10.1002/cbin.11292>
20. Zhou, Y., Sun, L., Zhu, M. et al. (2022) Effects and early diagnostic value of lncRNA H19 on sepsis-induced acute lung injury. Exp. Ther. Med. 23, 279. <https://doi.org/10.3892/etm.2022.11208>
21. Zhu, Y., Han, Q., Wang, L. et al. (2023) Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway. J. Ethnopharmacol. 301, 115763. <https://doi.org/10.1016/j.jep.2022.115763>
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