Fol. Biol. 2025, 71, 55-63
Endothelium and Systemic Inflammation in Neonates and Children
, Jana Dorňáková3,4, Jan Živný2, Jan Janota2,4
1Department of Paediatrics, Neonatology Unit, Hospital Most, Most, Czech Republic
2Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
3Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Prague, Czech Republic
4Department of Obstetrics and Gynaecology, Neonatal Unit, Motol University Hospital and Second Faculty of Medicine, Charles University, Prague, Czech Republic
Received August 2023
Accepted May 2025
The endothelium plays a crucial role in maintaining vascular homeostasis. Inflammation is initiated by activation of endothelial cells, which results in endothelial dysfunction. Dysfunction of the endothelium can have significant consequences in neonates and children. It is essential to understand the mechanisms underlying endothelial dysfunction in neonates and paediatric population to develop effective therapy interventions and improve outcomes. The aim of the review is to summarize the recent studies on the endothelium-associated molecules as biomarkers of systemic inflammatory conditions in the neonatal and paediatric population.
Keywords
endothelium, systemic inflammatory response syndrome, inflammation, neonates, children, multiple organ dysfunction syndrome, biomarkers of inflammation.
Funding
This study is supported by the Czech Health Research Council Agency (AZV), Ministry of Health of the Czech Republic, grant number NU20-07-00109.
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.