Fol. Biol. 2025, 71, 140-148
https://doi.org/10.14712/fb2025071030140
Atractylenolide III Promotes Astrocyte Aβ Clearance by Up-regulating AQP4 to Improve Alzheimer’s Disease
References
1. , B. T., Gebre, A. K., Altaye, B. M. (2018) Reactive astrocytes as drug target in Alzheimer’s disease. Biomed Res. Int. 2018, 4160247.
<https://doi.org/10.1155/2018/4160247>
2. , P., Jarvis, K. M., Montague, J. R. et al. (2007) Beta-amyloid toxicity in embryonic rat astrocytes. Neurochem. Res. 32, 1476-1482.
<https://doi.org/10.1007/s11064-007-9335-8>
3. , D. A., Boyd-Kimball, D. (2004) Amyloid β-peptide(1–42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain. Brain Pathol. 14, 426-432.
<https://doi.org/10.1111/j.1750-3639.2004.tb00087.x>
4. , W., Jie, S., Yajuan, T. et al. (2024) The rhizomes of Atractylodes macrocephala Koidz improve gastrointestinal health and pregnancy outcomes in pregnant mice via modulating intestinal barrier and water-fluid metabolism. J. Ethnopharmacol. 326, 117971.
<https://doi.org/10.1016/j.jep.2024.117971>
5. , S. S., Lee, H. J., Lim, I. et al. (2014) Human astrocytes: secretome profiles of cytokines and chemokines. PLoS One 9, e92325.
<https://doi.org/10.1371/journal.pone.0092325>
6. , S. S., Lee, S. R., Lee, H. J. (2016) Neurorestorative role of stem cells in Alzheimer’s disease: astrocyte involvement. Curr. Alzheimer Res. 13, 419-427.
<https://doi.org/10.2174/156720501304160314162812>
7. , W. S., Clarke, L. E., Wang, G. X. et al. (2013) Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature 504, 394-400.
<https://doi.org/10.1038/nature12776>
8. , I., Chiarini, A., Pacchiana, R. et al. (2014) Calcium-sensing receptors of human astrocyte-neuron teams: amyloid-β-driven mediators and therapeutic targets of Alzheimer’s disease. Curr. Neuropharmacol. 12, 353-364.
9. , S., Wu, C., Zou, P. et al. (2023) High-intensity interval training ameliorates Alzheimer’s disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization. Theranostics 13, 3434-3450.
<https://doi.org/10.7150/thno.81951>
10. , W., Zhang, Y., Wang, Z. et al. (2020) Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance. Alzheimers Res. Ther. 12, 125.
<https://doi.org/10.1186/s13195-020-00688-1>
11. , L., Lyra e Silva, N. M., Batista, A. F. et al. (2014) Alzheimer’s disease-like pathology induced by amyloid-β oligomers in nonhuman primates. J. Neurosci. 34, 13629-13643.
<https://doi.org/10.1523/JNEUROSCI.1353-14.2014>
12. , Y., Mucke, L. (2012) Alzheimer mechanisms and therapeutic strategies. Cell 148, 1204-1222.
<https://doi.org/10.1016/j.cell.2012.02.040>
13. , J. J., Wang, M., Liao, Y. et al. (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci. Transl. Med. 4, 147ra111.
<https://doi.org/10.1126/scitranslmed.3003748>
14. , Y. H., Li, W., Go, Y. et al. (2019) Atractylodis rhizoma alba attenuates neuroinflammation in BV2 microglia upon LPS stimulation by inducing HO-1 activity and inhibiting NF-κB and MAPK. Int. J. Mol. Sci. 20, 4015.
<https://doi.org/10.3390/ijms20164015>
15. , G. Q., Chen, R. Q.,Wang, L. (2016) Anti-inflammatory activity of atractylenolide III through inhibition of nuclear factor-κB and mitogen-activated protein kinase pathways in mouse macrophages. Immunopharmacol. Immunotoxicol. 38, 98-102.
<https://doi.org/10.3109/08923973.2015.1122617>
16. , S., Chun, H., Kim, Y. et al. (2024) Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease. Mol. Neurodegener. 19, 55.
<https://doi.org/10.1186/s13024-024-00740-w>
17. , E. G., Delgadillo, Y., White, R. E. et al. (2023) Beclin 1 regulates astrocyte phagocytosis and phagosomal recruitment of retromer. Tissue Cell 82, 102100.
<https://doi.org/10.1016/j.tice.2023.102100>
18. , C., Zhao, R., Gao, K. et al. (2011) Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer’s disease. Curr. Alzheimer Res. 8, 67-80.
<https://doi.org/10.2174/156720511794604543>
19. , G., Xie, R., Tan, Q. et al. (2024) Pharmacokinetic study and neuropharmacological effects of atractylenolide Ⅲ to improve cognitive impairment via PI3K/AKT/GSK3β pathway in intracerebroventricular-streptozotocin rats. J. Ethnopharmacol. 333, 118420.
<https://doi.org/10.1016/j.jep.2024.118420>
20. , Y., Wang, Q., Zhang, Y. (2016) A systems pharmacology approach to decipher the mechanism of danggui-shaoyao-san decoction for the treatment of neurodegenerative diseases. J. Ethnopharmacol. 178, 66-81.
<https://doi.org/10.1016/j.jep.2015.12.011>
21. , B., Spagnuolo, M. S., Cigliano, L. (2015) Haptoglobin modulates beta-amyloid uptake by U-87 MG astrocyte cell line. J. Mol. Neurosci. 56, 35-47.
<https://doi.org/10.1007/s12031-014-0465-6>
22. , L. J., Kobayashi, Y., Mogi, M. et al. (2017) Administration of bovine casein-derived peptide prevents cognitive decline in Alzheimer disease model mice. PLoS One 12, e0171515.
<https://doi.org/10.1371/journal.pone.0171515>
23. , S. D., Veerhuis, R., Blankenstein, M. A. et al. (2012) The effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes. Exp. Neurol. 233, 373-379.
<https://doi.org/10.1016/j.expneurol.2011.11.001>
24. , E. A., Ottersen, O. P. (2013) Physiological roles of aquaporin-4 in brain. Physiol. Rev. 93, 1543-1562.
<https://doi.org/10.1152/physrev.00011.2013>
25. , T. J., Keil, S. A., Han, W. et al. (2023) The effect of aquaporin-4 mis-localization on Aβ deposition in mice. Neurobiol. Dis. 181, 106100.
<https://doi.org/10.1016/j.nbd.2023.106100>
26. , W., Achariyar, T. M., Li, B. et al. (2016) Suppression of glymphatic fluid transport in a mouse model of Alzheimer’s disease. Neurobiol. Dis. 93, 215-225.
<https://doi.org/10.1016/j.nbd.2016.05.015>
27. , G. C., Catalin, B., Balseanu, T. A. et al. (2020) Inhibition of aquaporin 4 decreases amyloid Aβ40 drainage around cerebral vessels. Mol. Neurobiol. 57, 4720-4734.
<https://doi.org/10.1007/s12035-020-02044-8>
28. , P., De Strooper, B., Kivipelto, M. et al. (2021) Alzheimer’s disease. Lancet 397, 1577-1590.
<https://doi.org/10.1016/S0140-6736(20)32205-4>
29. , M., Wang, M. X., Ismail, O. et al. (2022) Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice. Alzheimers Res. Ther. 14, 59.
<https://doi.org/10.1186/s13195-022-00999-5>
30. , J. M., Carare, R. O., Osorio, R. S. et al. (2015) Clearance systems in the brain - implications for Alzheimer disease. Nat. Rev. Neurol. 11, 457-470.
<https://doi.org/10.1038/nrneurol.2015.119>
31. , D. R. (2012) The role of astrocytes in amyloid β-protein toxicity and clearance. Exp. Neurol. 236, 1-5.
<https://doi.org/10.1016/j.expneurol.2012.04.021>
32. , C., Kho, D. T., Costa, J. et al. (2013) Exposure to inflammatory cytokines IL-1β and TNFα induces compromise and death of astrocytes; implications for chronic neuroinflammation. PLoS One 8, e84269.
<https://doi.org/10.1371/journal.pone.0084269>
33. , K. T., Chen, L. G., Wu, C. H. et al. (2010) Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo. J. Pharm. Pharmacol. 62, 381-388.
<https://doi.org/10.1211/jpp.62.03.0014>
34. , Z., Chen, X.-C., Song, Y. et al. (2016) Amyloid β protein aggravates neuronal senescence and cognitive deficits in 5XFAD mouse model of Alzheimer’s disease. Chin. Med. J. (Engl.) 129, 1835-1844.
<https://doi.org/10.4103/0366-6999.186646>
35. , L., Jiang, C., Wang, Z. et al. (2016) Effect of Huperzine A on Aβ-induced p65 of astrocyte in vitro. Biosci. Biotechnol. Biochem. 80, 2334-2337.
<https://doi.org/10.1080/09168451.2016.1222265>
36. , Z., Xiao, N., Chen, Y. et al. (2015) Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits. Mol. Neurodegener. 10, 58.
<https://doi.org/10.1186/s13024-015-0056-1>
37. , W., Wu, Q., Yuan, C. et al. (2012) Aquaporin-4 mediates astrocyte response to β-amyloid. Mol. Cell. Neurosci. 49, 406-414.
<https://doi.org/10.1016/j.mcn.2012.02.002>
38. , F., Cao, R. L., Liu, P. et al. (2023) The bexarotene derivative OAB-14 ameliorates cognitive decline in APP/PS1 transgenic mice by suppressing microglia-mediated neuroinflammation through the PPAR-γ pathway. Int. Immunopharmacol. 124, 110911.
<https://doi.org/10.1016/j.intimp.2023.110911>
39. , H., Ji, Z. H., Liu, C., et al. (2015) Neuroprotection and mechanisms of atractylenolide III in preventing learning and memory impairment induced by chronic high-dose homocysteine administration in rats. Neuroscience 290, 485-491.
<https://doi.org/10.1016/j.neuroscience.2015.01.060>
40. , X., Sun, J., Xiong, L. et al. (2023) β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer’s disease. Int. J. Biol. Sci. 19, 3249-3265.
<https://doi.org/10.7150/ijbs.81900>
41. , B., Zhang, Q. L., Hua, J. W. et al. (2018) The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: a review. J. Ethnopharmacol. 226, 143-167.
<https://doi.org/10.1016/j.jep.2018.08.023>

