1Department of Dentistry, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic 2Department of Dentistry, University Hospital Hradec Králové, Hradec Králové, Czech Republic 3Department of Clinical Immunology and Allergology, University Hospital Hradec Králové, Hradec Králové, Czech Republic 4Department of Histology and Embryology, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic