Fol. Biol. 2026, 72, 85-94
https://doi.org/10.14712/fb2026.0009
MiR-26b-5p Predicts the Severity of Crohn’s Disease and the Degree of Malnutrition
References
1. , G., Lungaro, L., Caputo, F. et al. (2021) Nutritional treatment in Crohn’s disease. Nutrients 13, 1628.
<https://doi.org/10.3390/nu13051628>
2. , E., Wiest, R., Scharl, M. et al. (2021) Dysbiotic microbiota interactions in Crohn’s disease. Gut Microbes 13, 1949096.
<https://doi.org/10.1080/19490976.2021.1949096>
3. , H., Hughes, D., Kirkham, J.J. et al. (2019) Systematic review: outcomes and adverse events from randomised trials in Crohn’s disease. Aliment. Pharmacol. Ther. 49, 978-996.
<https://doi.org/10.1111/apt.15174>
4. , J. N., Omer, O. S., Tasker, S. et al. (2020) Regulatory T-cell therapy in Crohn’s disease: challenges and advances. Gut 69, 942-952.
<https://doi.org/10.1136/gutjnl-2019-319850>
5. , M., Torres, J., Vermeire, S. (2024) Crohn’s disease. Lancet 403, 1177-1191.
<https://doi.org/10.1016/S0140-6736(23)02586-2>
6. , J., Zhao, X., Hu, S. et al. (2022) Gut microbial DL-endopeptidase alleviates Crohn’s disease via the NOD2 pathway. Cell Host Microbe 30, 1435-1449.e9.
<https://doi.org/10.1016/j.chom.2022.08.002>
7. , Chinese Society of Gastroenterology, Chinese Medical Association (2021) Chinese consensus on diagnosis and treatment in inflammatory bowel disease (2018, Beijing). J. Dig. Dis. 22, 298-317.
<https://doi.org/10.1111/1751-2980.12994>
8. , B., Mrowiec, S. (2023) Nutritional status and its detection in patients with inflammatory bowel diseases. Nutrients 15, 1991.
<https://doi.org/10.3390/nu15081991>
9. , M., Kothari, S., Gohir, W. et al. (2023) MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets. Clin. Microbiol. Rev. 36, e0001523.
<https://doi.org/10.1128/cmr.00015-23>
10. , J., Rasmussen, H. H., Hamberg, O. et al. (2003) Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin. Nutr. 22, 321-336.
<https://doi.org/10.1016/S0261-5614(02)00214-5>
11. , E., Katsanos, K. H. (2016) Implementation of the simple endoscopic activity score in Crohn’s disease. Saudi J. Gastroenterol. 22, 183-191.
<https://doi.org/10.4103/1319-3767.182455>
12. , S. J., Lewis, A., Nijhuis, A., Jeffery, R. et al. (2018) Epithelial down-regulation of the miR-200 family in fibrostenosing Crohn’s disease is associated with features of epithelial to mesenchymal transition. J. Cell. Mol. Med. 22, 5617-5628.
<https://doi.org/10.1111/jcmm.13836>
13. , A., Abd-Aziz, N., Khalid, K. et al. (2022) miRNA: a promising therapeutic target in cancer. Int. J. Mol. Sci. 23, 11502.
<https://doi.org/10.3390/ijms231911502>
14. , P., Zhang, L., Li, S. et al. (2024) The emerging role of oxidative stress in inflammatory bowel disease. Front. Endocrinol. (Lausanne) 15, 1390351.
<https://doi.org/10.3389/fendo.2024.1390351>
15. Hoen, E. N., Van Rooij, E., Bushell, M. et al. (2015) The role of microRNA in nutritional control. J. Intern. Med. 278, 99-109.
<https://doi.org/10.1111/joim.12372>
16. , D., Cosín-Roger, J., Calatayud, S. et al. (2016) M1 macrophages activate Notch signalling in epithelial cells: relevance in Crohn’s disease. J. Crohns Colitis 10, 582-592.
<https://doi.org/10.1093/ecco-jcc/jjw009>
17. , G., Chrzanowski, G., Aebisher, D. et al. (2023) Crohn’s disease: basic characteristics of the disease, diagnostic methods, the role of biomarkers, and analysis of metalloproteinases: a review. Life (Basel) 13, 2062.
18. , L., Gori, R., Elli, L. et al. (2022) Nutrition in patients with inflammatory bowel diseases: a narrative review. Nutrients 14, 751.
<https://doi.org/10.3390/nu14040751>
19. , K., Le, N., von Arnim, U. et al. (2018) Circulating and fecal microRNAs as biomarkers for inflammatory bowel diseases. Inflamm. Bowel Dis. 24, 1547-1557.
<https://doi.org/10.1093/ibd/izy046>
20. , C. D. (2024) MicroRNAs and cardiovascular disease risk. Curr. Cardiol. Rep. 26, 51-60.
<https://doi.org/10.1007/s11886-023-02014-1>
21. , M. S., Satsangi, J., Ahmad, T. et al. (2005) Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can. J. Gastroenterol. 19 (Suppl. A), 5A-36A.
<https://doi.org/10.1155/2005/269076>
22. , J., Mehandru, S., Colombel, J. F. et al. (2017) Crohn’s disease. Lancet 389, 1741-1755.
<https://doi.org/10.1016/S0140-6736(16)31711-1>
23. , R., Bernstein, C. N., Gearry, R. et al. (2014) Antibiotics associated with increased risk of new-onset Crohn’s disease but not ulcerative colitis: a meta-analysis. Am. J. Gastroenterol. 109, 1728-1738.
<https://doi.org/10.1038/ajg.2014.246>
24. , K. L., Zheng, L. B., Kanazawa, Y. et al. (2014) Immunopathology of inflammatory bowel disease. World J. Gastroenterol. 20, 6-21.
<https://doi.org/10.3748/wjg.v20.i1.6>
25. , Z., Zhou, H., Cheng, F. et al. (2022) MiR-21 regulates epithelial-mesenchymal transition in intestinal fibrosis of Crohn’s disease by targeting PTEN/mTOR. Dig. Liver Dis. 54, 1358-1366.
<https://doi.org/10.1016/j.dld.2022.04.007>
26. , C.P., Bi, Y. J., Liu, D. M. et al. (2019) Hsa-miR-375 promotes the progression of inflammatory bowel disease by upregulating TLR4. Eur. Rev. Med. Pharmacol. Sci. 23, 7543-7549.
27. , F., Carlson, S. A., Liu, Y. et al. (2021) Prevalence of inflammatory bowel disease among medicare fee-for-service beneficiaries - United States, 2001-2018. MMWR Morb. Mortal. Wkly Rep. 70, 698-701.
<https://doi.org/10.15585/mmwr.mm7019a2>
28. , J., Guo, Z., Wang, Z. et al. (2023) Fecal miR-223 is a noninvasive biomarker for estimating Crohn’s disease activity. Immun. Inflamm. Dis. 11, e1131.
<https://doi.org/10.1002/iid3.1131>
29. , Q., Liu, Y., Li, Y. et al. (2025) Implications of gut microbiota-mediated epigenetic modifications in intestinal diseases. Gut Microbes 17, 2508426.
<https://doi.org/10.1080/19490976.2025.2508426>

