Fol. Biol. 2004, 50, 24-28
The Alterations of Immunological Reactivity in Heroin Addicts and Their Normalization in Patients Maintained on Methadone
Drug addiction influences many physiological functions including reactions of the immune system. The higher occurence of infectious and other diseases in drug addicts has been explained by the depression of immunity due to the harmful effects of the drug. To test this assumption, we tested the proliferative responsiveness and cytokine production of PBL from a group of heroin addicts (N = 19), patients maintained on methadone (N = 15) and healthy controls (N=15). The results show that Con A-induced proliferation of PBL from heroin addicts was even enhanced in comparison with PBL from the control group. Similarly, production of IL-2, IL-10 and IFNγ was higher in the group of heroin addicts than in healthy controls. The enhanced proliferation of PBL or the increased production of cytokines observed in heroin addicts was partially or completely normalized in the group of patients maintained on methadone. A significantly higher production of IL-6 was found in both unstimulated and stimulated PBL from heroin addicts and patients maintained on methadone, when compared with PBL from healthy controls. The results thus showed enhanced proliferative activity and increased production of various cytokines in heroin addicts and partial or complete adjustment of these alterations in patients maintained on methadone.
Funding
This work was supported by grants NF/6824-3 and NJ/6632-3 from the Ministry of Health of the Czech Republic, and projects LN00A026 and MSM 113100003 from the Ministry of Education of the Czech Republic
References
Copyright
This is an open-access article distributed under the terms of the Creative Commons Attribution License.