A Gly482Ser Polymorphism of the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (<i>PGC-1</i>) Gene Is Associated with Type 2 Diabetes in Caucasians

Kunej, T.; Globočnik Petrovič, M.; Dovč, P.; Peterlin, B.; Petrovič, Daniel

doi:10.14712/fb2004050050157

Fol. Biol. 2004, 50, 157-158

https://doi.org/10.14712/fb2004050050157

A Gly482Ser Polymorphism of the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1) Gene Is Associated with Type 2 Diabetes in Caucasians

T. Kunej¹, M. Globočnik Petrovič², P. Dovč¹, B. Peterlin³, Daniel Petrovič⁴

¹Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domzale, Slovenia
²Eye Clinic, University Medical Centre Ljubljana, Slovenia
³Division of Medical Genetics, Department of Obstetrics and Gynecology, Medical Centre Ljubljana, Slovenia
⁴Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Slovenia

Received August 2004
Accepted September 2004

The PGC-1 gene has been implicated in the regulation of several genes controlling energy metabolism. The prevalent Gly482Ser polymorphism of the PGC-1 gene has been shown to be associated with type 2 diabetes in some but not all studies. The aim of this study was to analyse whether the Gly482Ser variant is a risk factor for development of type 2 diabetes in Slovene population (Caucasians). Genotyping of the Gly482Ser polymorphism was performed for 545 subjects: 305 patients with type 2 diabetes and 240 nondiabetic controls. The Gly482Ser genotype distribution in patients with type 2 diabetes (AA = 11.5 %, AG = 42.3 %, GG = 46.2 %) differed from genotype distribution in non-diabetic controls (AA = 6.3 %, AG = 46.3 %, GG = 47.5 %), and the AA genotype was associated with 1.9-times increased risk of type 2 diabetes (95 % confidence interval 1.0-3.6; P = 0.036). In conclusion, we suggest that the AA genotype of the Gly482Ser polymorphism of the PGC-1 gene should be considered as a risk factor for the development of type 2 diabetes in Caucasians.