Folia Biologica
Journal of Cellular and Molecular Biology, Charles University 

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Fol. Biol. 2007, 53, 176-182

https://doi.org/10.14712/fb2007053050176

Halothane Does Not Directly Interact with Genome DNA of A549 Cells

Т. Тopouzova-Hristova1, R. Hazarosova2, B. Bandreva3, Elena Stephanova1

1Department of Cytology, Histology and Embryology, Faculty of Biology, University of Sofia, Sofia, Bulgaria
2Institute of Biophysics, Bulgarian Academy of Sciences, Sofia, Bulgaria
3Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria

Received May 2007
Accepted July 2007

References

1. Allaouchiche, B., Debon, R., Goudable, J., Chassard, D., Duflo, F. (2001) Oxidative stress status during exposure to propofol, sevoflurane and desflurane. Anesth. Analg. 93, 981-985. <https://doi.org/10.1097/00000539-200110000-00036>
2. Czene S., Testa E., Nygren J., Belyaev I., Harms-Ringdahl M. (2002) DNA fragmentation and morphological changes in apoptotic human lymphocytes. Biochem. Biophys. Res. Commun. 294, 872-878. <https://doi.org/10.1016/S0006-291X(02)00588-0>
3. Eliasson, E., Kenna, J. G. (1996) Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. Mol. Pharmacol. 50, 573-582.
4. Fujita, T., Maruyama, M., Araya, J., Sassa, K., Kawagishi, Y., Hayashi, R., Matsui, S., Kashii, T., Yamashita, N., Sugiyama, E., Kobayashi, M. (2002) Hydrogen peroxide induces upregulation of Fas in human airway epithelial cells via the activation of PARP-p53 pathway. Am. J. Resp. Cell Mol. Biol. 27, 542-552. <https://doi.org/10.1165/rcmb.4775>
5. Gualtieri, M., Rigamonti, L., Galeotti, V., Camatini, M. (2005) Toxicity of tire debris extracts on human lung cell line A549. Toxicol. in Vitro 19, 1001-1008. <https://doi.org/10.1016/j.tiv.2005.06.038>
6. Habre, W., Petak, F., Sly, P. D., Hantos, Z., Morel, D.R. (2001) Halothane is widely accepted as effecting in protecting against methacholine-induced airway constriction. Anesthesiology 94, 348-53. <https://doi.org/10.1097/00000542-200102000-00026>
7. Haitsma, J., Lachmann, R., Lachmann, B. (2003) Open lung in ARDS. Acta Pharmacol. Sin. 24, 1304-1307.
8. Holaday, D. A. (1977) Absorption, biotransformation and storage of halothane. Exp. Health Perspect. 21, 165-169. <https://doi.org/10.1289/ehp.7721165>
9. Hristov, K., Knox, K., Mitev, V. (2006) Differential regulation of Ramos Burkitt’s lymphoma B-cell line proliferation and BCR-triggered apoptosis following macromolecular protein synthesis inhibition. Comp. Rend. Acad. Bulg. Sci. 59, 425-430.
10. Jałoszynski, P., Kujawski, M., Wasowicz, M., Szulc, R., Szyfter, K. (1999) Genotoxicity of inhalation anesthetics halothane and isoflurane in human lymphocytes studied in vitro using the comet assay. Mutat. Res. 439, 199-206. <https://doi.org/10.1016/S1383-5718(98)00195-8>
11. Juvin, P., Clerici, C., Loiseau, A., Mantz, J., Aubier, M., Friedlander, G., Desmonts, J. M. (1999) Halothane stimulates a Na+H+ antiporter involved in the regulation of intracellular pH in alveolar epithelial cells. Anesth. Analg. 89, 480-483. <https://doi.org/10.1213/00000539-199908000-00044>
12. Kaech, S., Brinkhaus, H., Matus, A. (1999) Volatile anesthetics block actin-based motility in dendritic spines. Proc. Natl. Acad. Sci. USA 96, 10433-10437. <https://doi.org/10.1073/pnas.96.18.10433>
13. Kharasch, E., Schroeder, J., Liggitt, H., Park, S., Whittington, D., Sheffels, P. (2006) New insights into the mechanism of methoxyflurane nephrotoxixity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway. Anesthesiology 105, 726-736. <https://doi.org/10.1097/00000542-200610000-00019>
14. Klener Jr., P., Andĕra, L., Klener, P., Nečas, E., Živný, J. (2006) Cell death signalling pathways in the pathogenesis and therapy of haematologic malignancies: overview of apoptotic pathways. Folia Biol. (Praha) 52, 34-44.
15. Lalchev, Z. (2006) Phospholipid foam films – types, properties and applications, in: Colloid Stability – The Role of Surface Forces (vol. 1), Ed. T. Tadors, pp. 383-408, Wiley-VCH Verlag GmbH.
16. Lalchev, Z. I. (1997) Surface properties of lipids and proteins at bio-interfaces, in: Handbook of Surface and Colloid Chemistry, Ed. K.S. Birdi, pp. 625-687, CRC Press: Boca Raton, New York, London, Tokyo.
17. Lalchev, Z., Christova, Y., Todorov, R., Alexandrov, V., Stoichev, P., Petkov, R. (1992) Alterations of biochemical and physiological quantities of pulmonary lavages attending halothane and penthrane treatment in rats. Appl. Cardiopul. Pathophys. 4, 315-322.
18. Lestari, F., Hayes, A. J., Green, A. R., Markovic, B. (2005) In vitro cytotoxicity of selected chemicals commonly produced during fire combustion using human cell lines. Toxicol. in Vitro 19, 653-663. <https://doi.org/10.1016/j.tiv.2005.03.002>
19. Lieber, M., Smith, B., Szakal, A., Nelson-Rees, W., Rodaro, G. (1976) A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int. J. Cancer 17, 62-70. <https://doi.org/10.1002/ijc.2910170110>
20. Mitev, V., Miteva, L. (1999) Signal transduction in keratinocytes. Exp. Dermatol. 8, 96-108. <https://doi.org/10.1111/j.1600-0625.1999.tb00355.x>
21. Molliex, S., Crestani, B., Dureuil, B., Bastin, J., Rolland, C., Aubier, M., Desmonts, J. M. (1994) Effects of halothane on surfactant biosynthesis by rat alveolar type II cells in primary culture. Anesthesiology 81, 668-676. <https://doi.org/10.1097/00000542-199409000-00021>
22. Molliex, S., Dureuil, B., Aubier, M., Friedlander, G., Desmonts, J. M., Clerici, C. (1998) Halothane decreases Na, K-ATPase and Na channel activity in alveolar type II cells. Anesthesiology 88, 1606-1613. <https://doi.org/10.1097/00000542-199806000-00025>
23. Monig, J., Krischer, K., Asmus, K. D. (1983) One-electron reduction of halothane and formation of halide ions in aqueous solutions. Chem. Biol. Interact. 45, 43-52. <https://doi.org/10.1016/0009-2797(83)90041-8>
24. O’Keeffe, N. J., Healy, T. E. J. (1999) The role of new anesthetic agents. Pharmacol. Therapeut. 84, 233-248. <https://doi.org/10.1016/S0163-7258(99)00034-0>
25. Orrenius, S., Zhivotovsky, B., Nicotera, P. (2003) Regulation of cell death: The calcium-apoptosis link. Nat. Rev. Mol. Cell Biol. 4, 552-564. <https://doi.org/10.1038/nrm1150>
26. Patel, A. B., Sokolowski, J., Davidson, B. A., Knight, P. R., Holm, B. A. (2002) Halothane potentiation of hydrogen peroxide-induced inhibition of surfactant synthesis: the role of type II cell energy status. Anesth. Analg. 94, 943-947. <https://doi.org/10.1097/00000539-200204000-00031>
27. Sambrook, J., Fritsch, E., Maniatis, T. (1989) Analysis and cloning of eucaryotic genomic DNA, in: Molecular Cloning, a Laboratory Manual, Second ed., pp. 9.14-9.23, Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
28. Sardas, S., Aygun, N., Gamil, M., Unal, Y., Unal, N., Berk, N., Karakaya, A. (1998) Use of alkaline comet assay (single cell gel electrophoresis technique) to detect DNA damages in lymphocytes of operating personnel occupationally exposed to anesthetic gases. Mutat. Res. 418, 93-100. <https://doi.org/10.1016/S1383-5718(98)00113-2>
29. Smith, R., Porter, E., Miller, K. (1981) The solubility of anesthetic gases in lipid bilayers. Biochem. Bioph. Acta 645, 327-338 <https://doi.org/10.1016/0005-2736(81)90204-2>
30. Stimpfel, T., Gershey, E. L. (1991) Selecting anesthetic agents for human safety and animal recovery surgery. FASEB J. 5, 2099-2104. <https://doi.org/10.1096/fasebj.5.7.2010062>
31. Su, J. Y., Vo, A. C. (2002) Ca(2+)-calmodulin-dependent protein kinase II plays a major role in halothane-induced dose-dependent relaxation in the skinned pulmonary artery. Anesthesiology 97, 207-214. <https://doi.org/10.1097/00000542-200207000-00029>
32. Szyfer, K., Szulc, R., Mikstacki, A., Stachecki, I., Rydzanicz, M., Jałoszynski, P. (2004) Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo. Journal Appl. Genet. 45, 369-374.
33. Topouzova, T., Daza, P., Herdugo, G., Stephanova, E. (2003a) Assessment of genotoxicity of volatile anesthetic Penthrane to human lung cells. Ann. Univ. Sofia 95, 47-52.
34. Topouzova, T., Moreno, F. J., Daza, P., Stephanova, E. (2003b) Cytotoxic effect of inhalation anesthetics on human lung cells. Ann. Univ. Sofia 95, 53-58.
35. Topouzova-Hristova, T., Daza, P., Herdugo, G., Stephanova, E. (2006) Volatile anaesthetic halothane causes DNA damage in A549 lung cells. Toxicol. in Vitro 20, 585-593. <https://doi.org/10.1016/j.tiv.2005.10.004>
36. Valtcheva, R., Stephanova, E., Jordanova, A., Pankov, R., Altankov, G., Lalchev, Z. (2003) Effect of halothane on lung carcinoma cells. A 549. Chem.-Biol. Interact. 146, 191-200. <https://doi.org/10.1016/j.cbi.2003.08.002>
37. Vodicka P., Tuimala, J., Stetina, R., Kumar, R., Manini, P., Naccarati, A., Maestri, L., Vodickova, L., Kuricova, M., Järventaus, H., Majvaldova, Z., Hirvonen, A., Imbriani, M., Mutti, A., Migliore, L., Norppa, H., Hemminki, K. (2004) Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers. Environ. Health Perspect. 112, 867-871. <https://doi.org/10.1289/ehp.6849>
38. Walpole, R., Olday, J., Haetzman, M., Drummond, G. B., Doyle, E. (2001) A comparison of the respiratory effects of high concentrations of halothane and sevoflurane. Paediatr. Anaesth. 11, 157-160. <https://doi.org/10.1046/j.1460-9592.2001.00629.x>
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