Fol. Biol. 2019, 65, 227-236

https://doi.org/10.14712/fb2019065050227

Matrix Metalloproteinases and Their Tissue Inhibitors: an Evaluation of Novel Biomarkers in ANCA-Associated Vasculitis

Oskar Zakiyanov1, Z. Chocová1, Z. Hrušková1,2, Z. Hladinová1, Marta Kalousová3, K. Malíčková3, V. Bednářová1, J. Vachek1, P. Wurmová1, V. Kříha4, T. Zima3, V. Tesař1

1Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
2Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
3Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
4Institute of Radiation Oncology, Bulovka Hospital, Prague, Czech Republic

Received July 2019
Accepted October 2019

References

1. Bäck, M., Ketelhuth, D. F., Agewall, S. (2010) Matrix metalloproteinases in atherothrombosis. Prog. Cardiovasc. Dis. 52, 410-428. <https://doi.org/10.1016/j.pcad.2009.12.002>
2. Bauvois, B., Mothu, N., Nguyen, J., Nguyen-Khoa, T., Nöel, L. H., Jungers, P. (2007) Specific changes in plasma concentrations of matrix metalloproteinase-2 and -9, TIMP-1 and TGF-β1 in patients with distinct types of primary glomerulonephritis. Nephrol. Dial. Transplant. 22, 1115-1122. <https://doi.org/10.1093/ndt/gfl743>
3. Bjerkeli, V., Halvorsen, B., Damås, J. K., Nordøy, I., Yndestad, A., Aukrust, P., Frøland, S. S. (2004) Expression of matrix metalloproteinases in patients with Wegener’s granulomatosis. Ann. Rheum. Dis. 63, 1659-1663. <https://doi.org/10.1136/ard.2003.017954>
4. Boldt, H. B., Conover, C. A. (2007) Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs. Growth Horm. IGF Res. 17, 10-18. <https://doi.org/10.1016/j.ghir.2006.11.003>
5. Bonnema, D. D., Webb, C. S., Pennington, W. R., Stroud, R. E., Leonardi, A. E., Clark, L. L., McClure, C. D., Finklea, L., Spinale, F. G., Zile, M. R. (2007) Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). J. Card. Fail. 13, 530-540. <https://doi.org/10.1016/j.cardfail.2007.04.010>
6. Busiek, D. F., Baragi, V., Nehring, L. C., Parks, W C., Welgus, H. G. (1995) Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones. J. Immunol. 154, 6484-6491. <https://doi.org/10.4049/jimmunol.154.12.6484>
7. Carome, M. A., Striker, L. J., Peten, E. P., Moore, J., Yang, C. W., Stetler-Stevenson, W. G., Striker, G. E. (1993) Human glomeruli express TIMP-1 mRNA and TIMP-2 protein and mRNA. Am. J. Physiol. 264, F923-929.
8. Cheng, S., Lovett, D. H. (2003) Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am. J. Pathol. 162, 1937-1949. <https://doi.org/10.1016/S0002-9440(10)64327-1>
9. Chromek, M., Tullus, K., Lundahl, J., Brauner, A. (2004) Tissue inhibitor of metalloproteinase 1 activates normal human granulocytes, protects them from apoptosis, and blocks their transmigration during inflammation. Infect. Immun. 72, 82-88. <https://doi.org/10.1128/IAI.72.1.82-88.2004>
10. Conklin, L. S., Merkel, P. A., Pachman, L. M., Parikh, H., Tawalbeh, S., Damsker, J. M., Cuthbertson, D. D., Morgan, G. A., Monach, P. A., Hathout, Y., Nagaraju, K., van den Anker, J., McAlear, C. A., Hoffman, E. P. (2018) Serum biomarkers of glucocorticoid response and safety in antineutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis. Steroids 140, 159-166. <https://doi.org/10.1016/j.steroids.2018.10.008>
11. de Leeuw, K., Sanders, J. S., Stegeman, C., Smit, A., Kallenberg, C. G., Bijl, M. (2005) Accelerated atherosclerosis in patients with Wegener’s granulomatosis. Ann. Rheum. Dis. 64, 753-759. <https://doi.org/10.1136/ard.2004.029033>
12. Faber-Elmann, A., Sthoeger, Z., Tcherniack, A., Dayan, M., Mozes, E. (2002) Activity of matrix metalloproteinase-9 is elevated in sera of patients with systemic lupus erythematosus. Clin. Exp. Immunol. 127, 393-398. <https://doi.org/10.1046/j.1365-2249.2002.01758.x>
13. Falk, R. J., Jennette, J. C. (1997) ANCA small-vessel vasculitis. J. Am. Soc. Nephrol. 8, 314-322. <https://doi.org/10.1681/ASN.V82314>
14. Gomez, D. E., Alonso, D. F., Yoshiji, H., Thorgeirsson, U. P. (1997) Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Eur. J. Cell Biol. 74, 111-122.
15. Ishizaki, J., Takemori, A., Suemori, K., Matsumoto, T., Akita, Y., Sada, K. E., Yuzawa, Y., Amano, K., Takasaki, Y., Harigai, M., Arimura, Y., Makino, H., Yasukawa, M., Takemori, N., Hasegawa, H., Research Committee of Intractable Vasculitis Syndrome and the Research Committee of Intractable Renal Disease of the Ministry of Health Labour and Welfare of Japan (2017) Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Res. Ther. 19, 218. <https://doi.org/10.1186/s13075-017-1429-3>
16. Jennette, J. C., Falk, R. J. (1997) Small-vessel vasculitis. N. Engl. J. Med. 337, 1512-1523. <https://doi.org/10.1056/NEJM199711203372106>
17. Jennette, J. C., Falk, R. J., Bacon, P. A., Basu, N., Cid, M. C., Ferrario, F., Flores-Suarez, L. F., Gross, W. .L, Guillevin, L., Hagen, E. C., Hoffman, G. S., Jayne, D. R., Kallenberg, C. G., Lamprecht, P., Langford, C. A., Luqmani, R. A., Mahr, A. D., Matteson, E. L., Merkel, P. A., Ozen, S., Pusey, C. D., Rasmussen, N., Rees, A. J., Scott, D. G., Specks, U., Stone, J. H., Takahashi, K., Watts, R. A. (2013) 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 65, 1-11. <https://doi.org/10.1002/art.37715>
18. Kalousová, M., Tesař, V., Muravská, A., Zima, T. (2012) Pregnancy- associated plasma protein A: spotlight on kidney diseases. Clin. Chem. Lab. Med. 50, 1183-1190. <https://doi.org/10.1515/cclm-2011-0640>
19. Keeling, J., Herrera, G. A. (2008) Human matrix metalloproteinases: characteristics and pathologic role in altering mesangial homeostasis. Microsc. Res. Tech. 71, 371-379. <https://doi.org/10.1002/jemt.20565>
20. Lauhio, A., Hästbacka, J., Pettilä, V., Tervahartiala, T., Karlsson, S., Varpula, T., Varpula, M., Ruokonen, E., Sorsa, T., Kolho, E. (2011) Serum MMP-8, -9 and TIMP-1 in sepsis: high serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines. Pharmacol. Res. 64, 590-594. <https://doi.org/10.1016/j.phrs.2011.06.019>
21. Lauzurica, R., Pastor, C., Bayés, B., Hernández, J. M., Romero, R. (2005) Pretransplant pregnancy-associated plasma protein-A as a predictor of chronic allograft nephropathy and posttransplant cardiovascular events. Transplantation 80, 1441-1446. <https://doi.org/10.1097/01.tp.0000185199.67531.1a>
22. Lawrence, J. B., Oxvig, C., Overgaard, M. T., Sottrup-Jensen, L., Gleich, G. J., Hays, L. G., Yates, J. R., Conover, C. A. (1999) The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc. Natl. Acad. Sci. USA 96, 3149-3153. <https://doi.org/10.1073/pnas.96.6.3149>
23. Lenz, O., Elliot, S. J., Stetler-Stevenson, W. G. (2000) Matrix metalloproteinases in renal development and disease. J. Am. Soc. Nephrol. 11, 574-581. <https://doi.org/10.1681/ASN.V113574>
24. Monach, P. A., Tomasson, G., Specks, U., Stone, J. H., Cuthbertson, D., Krischer, J., Ding, L., Fervenza, F. C., Fessler, B. J., Hoffman, G. S., Ikle, D., Kallenberg, C. G., Langford, C. A., Mueller, M., Seo, P., St Clair, E. W., Spiera, R., Tchao, N., Ytterberg, S. R., Gu, Y. Z., Snyder, R. D., Merkel, P. A. (2011) Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum. 63, 3988-3997. <https://doi.org/10.1002/art.30615>
25. Monach, P. A., Warner, R. L., Tomasson, G., Specks, U., Stone, J. H., Ding, L., Fervenza, F. C., Fessler, B. J., Hoffman, G. .S, Iklé, D., Kallenberg, C. G., Krischer, J., Langford, C. A., Mueller, M., Seo, P., St Clair, E. W., Spiera, R., Tchao, N., Ytterberg, S. R., Johnson, K. J., Merkel, P. A. (2013) Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis. Ann. Rheum. Dis. 72, 1342-1350. <https://doi.org/10.1136/annrheumdis-2012-201981>
26. Monach, P. A. (2014) Biomarkers in vasculitis. Curr. Opin. Rheumatol. 26, 24-30. <https://doi.org/10.1097/BOR.0000000000000009>
27. Mühl, D., Nagy, B., Woth, G., Falusi, B., Bogár, L., Weber, G., Lantos, J. (2011) Dynamic changes of matrix metalloproteinases and their tissue inhibitors in severe sepsis. J. Crit. Care 26, 550-555. <https://doi.org/10.1016/j.jcrc.2011.02.011>
28. Oelusarz, A., Nichols, L. A., Grunz-Borgmann, E. A., Chen, G., Akintola, A. D., Catania, J. M., Burghardt, R. C., Trzeciakowski, J. P., Parrish, A. R. (2013) Overexpression of MMP-7 increases collagen 1A2 in the aging kidney. Physiol. Rep. 1, pii: e00090
29. Olson, M. W., Toth, M., Gervasi, D. C., Sado, Y., Ninomiya, Y., Fridman, R. (1998) High affinity binding of latent matrix metalloproteinase-9 to the α2(IV) chain of collagen IV. J. Biol. Chem. 273, 10672-10681. <https://doi.org/10.1074/jbc.273.17.10672>
30. Reindel, R., Baker, S. C., Kim, K. Y., Rowley, C. A., Shulman, S. T., Orenstein, J. M., Perlman, E. J., Lingen, M. W., Rowley, A. H. (2013) Integrins α4 and αM, collagen1A1, and matrix metalloproteinase 7 are upregulated in acute Kawasaki disease vasculopathy. Pediatr. Res. 73, 332-336. <https://doi.org/10.1038/pr.2012.185>
31. Robak, E., Wierzbowska, A., Chmiela, M., Kulczycka, L., Sysa-Jedrejowska, A., Robak, T. (2006) Circulating total and active metalloproteinase-9 and tissue inhibitor of metalloproteinases- 1 in patients with systemic lupus erythomatosus. Mediators Inflamm. 2006, 17898. <https://doi.org/10.1155/MI/2006/17898>
32. Ruth, A. J., Kitching, A. R., Kwan, R. Y., Odobasic, D., Ooi, J. D., Timoshanko, J. R., Hickey, M. J., Holdsworth, S. R. (2006) Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis. J. Am. Soc. Nephrol. 17, 1940-1949. <https://doi.org/10.1681/ASN.2006020108>
33. Sanders, J. S., van Goor, H., Hanemaaijer, R., Kallenberg, C. G., Stegeman, C. A. (2004) Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis. Nephrol. Dial. Transplant. 19, 1412-1419. <https://doi.org/10.1093/ndt/gfh186>
34. Sanders, J. S., Huitema, M. G., Hanemaaijer, R., van Goor, H., Kallenberg, C. G., Stegeman, C. A. (2007) Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis. Am. J. Physiol. Renal Physiol. 293, F1927-1934. <https://doi.org/10.1152/ajprenal.00310.2007>
35. Stone, J. H., Hoffman, G. S., Merkel, P. A., Min, Y. I., Uhlfelder, M. L., Hellmann, D. B., Specks, U., Allen, N. B., Davis, J. C., Spiera, R. F., Calabrese, L. H., Wigley, F. M., Maiden, N., Valente, R. M., Niles, J. L., Fye, K. H., McCune, J. W., St Clair, E. W., Luqmani, R. A. (INSSYS). (2001) A disease-specific activity index for Wegener’s granulomatosis modification of the Birmingham Vasculitis Activity Score. International Network for the Study of the Systemic Vasculitides (INSSYS). Arthritis Rheum. 44, 912-920. <https://doi.org/10.1002/1529-0131(200104)44:4<912::AID-ANR148>3.0.CO;2-5>
36. Sundstrom, J., Evans, J. C., Benjamin, E. J., Levy, D., Larson, M. G., Sawyer, D. B., Siwik, D. A., Colucci, W. S., Wilson, P. W., Vasan, R. S. (2004) Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham Heart Study. Eur. Heart J. 25, 1509-1516. <https://doi.org/10.1016/j.ehj.2004.05.029>
37. Swee, M., Wilson, C. L., Wang, Y., McGuire, J. K., Parks, W. C. (2008) Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients. J. Leukoc. Biol. 83, 1404-1412. <https://doi.org/10.1189/jlb.0108016>
38. Tayebjee, M. H., Lip, G. Y., Blann, A. D., Macfydyen, R. J. (2004) Effects of age, gender, ethnicity, diurnal variation and exercise on circulating levels of matrix metalloproteinases (MMP)-2 and -9, and their inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP)-1 and 2. Thromb. Res. 115, 205-210. <https://doi.org/10.1016/j.thromres.2004.08.023>
39. Turck, J., Pollock, A. S., Lee, L. K., Marti, H. P., Lovett, D. H. (1996) Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation. J. Biol. Chem. 271, 15074-15083. <https://doi.org/10.1074/jbc.271.25.15074>
40. Van den Steen, P. E., Proost, P., Wuyts, A., Van Damme, J., Opdenakker, G. (2000) Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact. Blood 96, 2673-2681. <https://doi.org/10.1182/blood.V96.8.2673>
41. Van Lint, P., Libert, C. (2006) Matrix metalloproteinase-8: cleavage can be decisive. Cytokine Growth Factor Rev. 17, 217-223. <https://doi.org/10.1016/j.cytogfr.2006.04.001>
42. Watanabe, R., Maeda, T., Zhang, H., Berry, G. J., Zeisbrich, M., Brockett, R., Greenstein, A. E., Tian, L., Goronzy, J. J., Weyand, C. M. (2018) MMP (matrix metalloprotease)- 9-producing monocytes enable T cells to invade the vessel wall and cause vasculitis. Circ. Res. 123, 700-715. <https://doi.org/10.1161/CIRCRESAHA.118.313206>
43. Zakiyanov, O., Kalousová, M., Kratochvilová, M., Kríha, V., Zima, T., Tesar, V. (2013) Changes in levels of matrix metalloproteinase- 2 and -9, pregnancy-associated plasma protein- A in patients with various nephropathies. J. Nephrol. 26, 502-509. <https://doi.org/10.5301/jn.5000136>
44. Zakiyanov, O., Kalousová, M., Zima, T., Tesař, V. (2019) Matrix metalloproteinases in renal diseases: a critical appraisal. Kidney Blood Press. Res. 44, 298-330. <https://doi.org/10.1159/000499876>
front cover

ISSN 0015-5500 (Print) ISSN 2533-7602 (Online)

Open access journal

Archive